3586-58-1

Usage

Uses

Used in Chemical Synthesis Industry:
2-Ethylacrylic Acid 98 is used as a monomer for the production of polymers and copolymers, which are essential in the development of various materials with tailored properties. Its alpha, beta-unsaturated bond allows for easy copolymerization with other monomers, resulting in materials with improved characteristics such as enhanced mechanical strength, flexibility, and chemical resistance.
Used in Adhesives and Sealants Industry:
2-Ethylacrylic Acid 98 is used as a reactive diluent or crosslinking agent in the formulation of adhesives and sealants. Its ability to copolymerize with other monomers allows for the creation of adhesives with specific properties, such as increased adhesion, improved durability, and resistance to environmental factors.
Used in Coatings Industry:
In the coatings industry, 2-Ethylacrylic Acid 98 is used as a comonomer to modify the properties of coatings. Its incorporation into coating formulations can lead to improved adhesion, durability, and resistance to chemicals, UV light, and weathering.
Used in Textile Industry:
2-Ethylacrylic Acid 98 is used in the textile industry for the development of specialty fibers and fabrics. Its copolymerization with other monomers can result in fibers with enhanced mechanical properties, improved dyeability, and increased resistance to environmental factors.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Ethylacrylic Acid 98 can be used as an intermediate in the synthesis of various drug molecules. Its unique chemical structure allows for the development of new compounds with potential therapeutic applications.
Used in Agriculture Industry:
2-Ethylacrylic Acid 98 can be used in the agriculture industry for the development of novel agrochemicals, such as herbicides, pesticides, and fertilizers. Its chemical properties can be harnessed to create products with improved efficacy, reduced environmental impact, and increased selectivity for target organisms.

InChI:InChI=1/C5H8O2/c1-3-4(2)5(6)7/h2-3H2,1H3,(H,6,7)

Upstream product

• 4359-77-7 3-ethyl-3-buten-2-one 
• 3739-30-8 2-hydroxy-2-methylbutyric acid 
• 4374-62-3 2-hydroxymethyl-butyric acid 
• 99437-71-5 ethyl 2-(hydroxymethyl)butanoate 
• 98485-66-6 ethyl-hydroxymethyl-malonic acid 
• 57271-95-1 ethyl-methylaminomethyl-malonic acid 
• 50-00-0 formaldehyd 
• 80-58-0 2-Bromobutyric acid 
• 96-17-3 2-Methylbutyraldehyde 
• 23074-36-4 2-bromobutene 
• 124-38-9 carbon dioxide 
• 3070-65-3 ethyl 2-methylenebutyrate 
• 67-56-1 methanol 
• 922-63-4 ethylacrolein 

Downstream Products

• 80-59-1 Tiglic acid 
• 4390-96-9 2-ethylacryloyl chloride 
• 78-93-3 butanone 
• 95383-64-5 2-Ethylacrylsaeureanilid 
• 219506-75-9 2-benzyloxycarbonyl-1-butene 
• 6622-76-0 methyl (E)-2-methyl-2-butenoate 
• 2177-67-5 methyl 2-ethylacrylate 
• 64-18-6 formic acid 
• 329928-73-6 2-hydroxy-2-hydroxymethyl-butyric acid 
• 802294-64-0 propionic acid 
• 350010-25-2 2-Methylene-butyric acid (3R,3aR,6S,6aR)-6-benzyloxy-hexahydro-furo[3,2-b]furan-3-yl ester 
• 62721-35-1 2-chloro-2-methylbutyryl chloride 
• 888071-25-8 N-(4-cyano-3-trifluoromethyl-phenyl)-2-ethyl-acrylamide 
• 888072-04-6 3-ethyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide 

Relevant academic research and scientific papers

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent cou

Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution. Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones through a Michael addition.

INHIBITORS OF CYCLIN-DEPENDENT KINASES

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY

The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Macrolactam Synthesis via Ring-Closing Alkene-Alkene Cross-Coupling Reactions

Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.

INHIBITORS OF CYCLIN-DEPENDENT KINASES

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

A new type of domino reaction for synthesis of heterocycles fusing the important bioactive cores, such as oxindole, indoline, and isoquinoline, is presented. Upon exposure to the very common palladium catalyst, the conceptually designed N-alkenyl iodobiaryls undergo a sequential carbopalladation/C-H activation to build polycyclic frameworks. These novel unique frameworks may provide structure sources in fragment-based drug discovery.

Deciphering Nature's Intricate Way of N,S-Dimethylating l -Cysteine: Sequential Action of Two Bifunctional Adenylation Domains

Dimethylation of amino acids consists of an interesting and puzzling series of events that could be achieved, during nonribosomal peptide biosynthesis, either by a single adenylation (A) domain interrupted by a methyltransferase (M) domain or by the sequential action of two of such independent enzymes. Herein, to establish the method by which Nature N,S-dimethylates l-Cys, we studied its formation during thiochondrilline A biosynthesis by evaluating TioS(A3aM3SA3bT3) and TioN(AaMNAb). This study not only led to identification of the exact pathway followed in Nature by these two enzymes for N,S-dimethylation of l-Cys, but also revealed that a single interrupted A domain can N,N-dimethylate amino acids, a novel phenomenon in the nonribosomal peptide field. These findings offer important and useful insights for the development and engineering of novel interrupted A domain enzymes to serve, in the future, as tools for combinatorial biosynthesis.

Synthesis of Enantiomerically Enriched 2-Hydroxymethylalkanoic Acids by Oxidative Desymmetrisation of Achiral 1,3-Diols Mediated by Acetobacter aceti

The stereoselective desymmetrisation of achiral 2-alkyl-1,3-diols is performed by oxidation of one of the two enantiotopic primary alcohol moieties by means of Acetobacter aceti MIM 2000/28 to afford the corresponding chiral 2-hydroxymethyl alkanoic acids (up to 94 % ee). The procedure, carried out in aqueous medium under mild conditions of pH, temperature and pressure, contributes to enlarge the portfolio of enzymatic oxidations available to organic chemists for the development of sustainable manufacturing processes.