1531618-40-2Relevant academic research and scientific papers
Fluorescent probes of the isoxazole-dihydropyridine scaffold: MDR-1 binding and homology model Dedicated to the memory of Professor Robert O. Hutchins, peerless mentor and good friend
Szabon-Watola, Monika I.,Ulatowski, Sarah V.,George, Kathleen M.,Hayes, Christina D.,Steiger, Scott A.,Natale, Nicholas R.
, p. 117 - 121 (2014/01/17)
Isoxazole-1,4-dihydropyridines (IDHPs) were tethered to fluorescent moieties using double activation via a lanthanide assisted Weinreb amidation. IDHP-fluorophore conjugate 3c exhibits the highest binding to date for IDHPs at the multidrug-resistance transporter (MDR-1), and IDHP-fluorophore conjugates 3c and 7 distribute selectively in SH-SY5Y cells. A homology model for IDHP binding at MDR-1 is presented which represents our current working hypothesis.
