1531624-14-2Relevant academic research and scientific papers
3- season carbon chiral -C-acyl Phthalidyl derivative and its preparation method
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Paragraph 0161; 0162; 0163; 0164; 0165; 0166; 0167, (2016/10/17)
The invention discloses a 3-quaternary carbon chiral-C-acylbenzofuranone derivative and a preparation method thereof. O-acylbenzofuranone derivative as a raw material undergoes an asymmetric Black rearrangement reaction in the presence of a chiral imidazole catalyst to produce the 3-quaternary carbon chiral-C-acylbenzofuranone derivative. The preparation method utilizes a cheap and easily available chiral nucleophilic catalyst to replace an expensive catalyst used in the prior art, has mild catalytic reaction conditions and simple processes, and has a good yield and enantioselectivity. Through further derivation, the obtained 3-quaternary carbon chiral-C-acylbenzofuranone derivative can be used for synthesis of a physiologically active molecule.
Enantioselective Black rearrangement catalyzed by chiral bicyclic imidazole
Wang, Mingli,Zhang, Zhenfeng,Liu, Shan,Xie, Fang,Zhang, Wanbin
supporting information, p. 1227 - 1230 (2014/02/14)
A newly developed chiral imidazole nucleophilic catalyst, Acyloxy-DPI, was readily prepared and successfully applied to the enantioselective Black rearrangement with up to 88% ee for a wide range of substrates possessing different substituted groups. A pl
