65817-24-5

Usage

Explanation

The compound is also referred to as Famprofazone in the field of pharmaceuticals and medicine.

Explanation

2-(4-Methyl-2-hydroxyphenyl)propionic acid gamma-lactone belongs to the class of propionic acids, which are a group of organic compounds.

Explanation

It is a lactone derivative, which means it has a cyclic ester structure in its molecular composition.

Explanation

The compound has been studied for its potential to relieve pain (analgesic) and reduce inflammation (anti-inflammatory) in the body.

Explanation

Famprofazone has been investigated for its ability to inhibit the formation of prostaglandins, which are chemicals that play a role in the body's inflammatory response.

Explanation

The compound has been studied for its potential to effectively relieve pain in various conditions.

Explanation

2-(4-Methyl-2-hydroxyphenyl)propionic acid gamma-lactone is used in the synthesis of various pharmaceuticals and research chemicals, contributing to the development of new medications.

Chemical class

Propionic acids

Structure

Lactone derivative

Pharmaceutical applications

Potential analgesic and anti-inflammatory properties

Inhibition of prostaglandins

Involved in inflammatory response

Pain relief

Potential as an effective pain reliever

Synthesis

Pharmaceutical and research chemicals

InChI:InChI=1/C10H10O2/c1-6-3-4-8-7(2)10(11)12-9(8)5-6/h3-5,7H,1-2H3

Upstream product

• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 35633-35-3 2-methoxy-4-methylacetophenone 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 137408-21-0 3(4)-vinylbenzyl alcohol 
• 698-27-1 4-methylsalicylaldehyde 
• 600-22-6 pyruvic acid methyl ester 
• 108-39-4 3-methyl-phenol 
• 80417-97-6 3,6-dimethyl-5,6-dihydrobenzofuran-2(4H)-one 
• 105-76-0 Dibutyl maleate 
• 331626-90-5 methyl 2-(2-methoxy-4-methylphenyl)propanethiolate 
• 221354-43-4 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione 
• 221354-52-5 methyl 2-<4-methyl-2-methoxyphenyl>ethanethioate 
• 122-46-3 3-acetoxytoluene 

Downstream Products

• 238752-84-6 3-(3-butenyl)-3,6-dimethyl-2,3-dihydrobenzo[b]furan-2-one 
• 64052-99-9 rel-(3S,3aS,8bS)-7-bromo-3,6,8b-trimethyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-3a-carbaldehyde 
• 13341-72-5 menthalactone 
• 1531624-14-2 3,6-dimethylbenzofuran-2-yl phenyl carbonate 
• 1531624-35-7 (R)-phenyl 3,6-dimethyl-2-oxo-2,3-dihydrobenzofuran-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of Benzofuranones via Palladium-Catalyzed Intramolecular Alkoxycarbonylation of Alkenylphenols

Herein, a new catalytic system to synthesize benzofuranones is reported. A palladium-catalyzed intramolecular alkoxycarbonylation is employed to generate 3-substituted-benzofuran-2(3H)-ones from alkenylphenols under mild reaction conditions, linked to an ex situ formation of CO from N-formylsaccharin. The carefully chosen catalytic system enables an efficient reaction with a novel functional group tolerance, despite the high polymerization tendency of the starting material.

Direct enantioselective: C -acylation for the construction of a quaternary stereocenter catalyzed by a chiral bicyclic imidazole

A direct enantioselective C-acylation of 3-substituted benzofuran-2(3H)-ones (with up to 97% ee) was developed using a chiral bicyclic imidazole catalyst OAc-DPI and an achiral tertiary amine additive DIPEA. The reaction mechanism for the direct C-acylation has been investigated using both experimental and theoretical studies.

Use of 3,6-dimethyl-2(3H)-benzofuranone as flavor material and new process for its preparation

3,6-Dimethyl-2(3H)-benzofuranone is a new, valuable flavor material. A process for its industrial-scale preparation was developed.

The synthesis of a natural product family: From debromoisolaurinterol to the aplysins

Total syntheses of (±)-aplysin 1, (±)-debromoaplysin 2, (±)-isoaplysin 3, (±)-aplysinol 4, (±)-debromoaplysinol 5, (±)-aplysinal 6, (±)-isolaurinterol 7 and (±)-debromoisolaurinterol 8 are described. Key features are a diastereoselective, sulfur mediated radical cyclisation of diene 12 to give 35; a new radical to polar crossover sequence mediated by Bu3Sn that transforms diene 12 into (±)-debromoisolaurinterol 8; and a series of biomimetic cyclisation and oxidation reactions.