1531629-08-9Relevant academic research and scientific papers
Cobalt(II)-Catalyzed Electrooxidative C-H Amination of Arenes with Alkylamines
Gao, Xinlong,Wang, Pan,Zeng, Li,Tang, Shan,Lei, Aiwen
, p. 4195 - 4199 (2018)
An environmentally friendly electrochemical protocol about cobalt-catalyzed C-H amination of arenes has been developed, which offers a simple way to access synthetically useful arylamines. In divided cells, a wide variety of arenes and alkylamines are exa
Synthesis method of N-8-quinolyl-2-amino benzamide compound
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Paragraph 0017-0022, (2021/07/17)
The invention discloses a synthesis method of an N-8-quinolyl-2-amino benzamide compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: by taking N-8-quinolyl aryl amide as a reaction raw material, cuprous iodide as a catalyst and O-benzoyl hydroxylamine as an amination reagent, carrying out heating reaction in an organic solvent in the presence of inorganic alkali, so as to obtain the N-8-quinolyl-2-amino benzamide compound. The synthesis method is convenient to operate, mild in condition, simple in process, wide in application range of substrate functional groups, good in amination reaction regioselectivity and high in yield.
Copper-Catalyzed Intermolecular C(sp2)-H Amination with Electrophilic O-Benzoyl Hydroxylamines
Rao, Wei-Hao,Li, Qi,Jiang, Li-Li,Deng, Xue-Wan,Xu, Pan,Chen, Fang-Yuan,Li, Ming,Zou, Guo-Dong
, p. 10580 - 10590 (2021/08/20)
A copper-catalyzed intermolecular electrophilic amination of benzamides with O-benzoyl hydroxylamines was achieved with the assistance of an 8-aminoquinolyl group. With this protocol, good compatibility was observed for a variety of aryl amides and hetero
Cobalt-Catalyzed Direct Amination of Arenes with Alkylamines via Bidentate-Chelation Assistance
Yan, Qiangqiang,Xiao, Tangxin,Liu, Zhanxiang,Zhang, Yuhong
supporting information, p. 2707 - 2711 (2016/08/30)
Cobalt-catalyzed C?H amination of arenes with alkylamines by the assistance of 8-aminoquinoline as auxiliary through sp2C?H bond functionalization has been achieved. Attractive features of this protocol include the low loading of the cobalt catalyst and the readily available reagents. (Figure presented.).
Nickel-Catalyzed Direct Amination of Arenes with Alkylamines
Yan, Qiangqiang,Chen, Zhengkai,Yu, Wenlong,Yin, Hong,Liu, Zhanxiang,Zhang, Yuhong
supporting information, p. 2482 - 2485 (2015/05/27)
(Figure Presented) The efficient nickel-catalyzed direct amination of arenes with simple alkylamines has been achieved with the assistance of a bidentate directing group through sp2 C-H bond functionalization. Preliminary mechanistic investigations indicate that the reaction probably proceeds through a NiI/NiIII catalytic pathway.
Synthesis of anthranilic acid derivatives through iron-catalyzed ortho amination of aromatic carboxamides with N-chloroamines
Matsubara, Tatsuaki,Asako, Sobi,Ilies, Laurean,Nakamura, Eiichi
supporting information, p. 646 - 649 (2014/02/14)
Arenes possessing an 8-quinolinylamide group as a directing group are ortho aminated with N-chloroamines and N-benzoyloxyamines in the presence of an iron/diphosphine catalyst and an organometallic base to produce anthranilic acid derivatives in high yield. The reaction proceeds via iron-catalyzed C-H activation, followed by the reaction of the resulting iron intermediate with N-chloroamine. The choice of the directing group and diphosphine ligand is crucial for obtaining the anthranilic acid derivative with high yield and product selectivity.
