1531629-09-0

Basic information

• Product Name: N-(quinolin-8-yl)-2-(N-morpholino)-5-methylbenzamide
• Synonyms: N-(quinolin-8-yl)-2-(N-morpholino)-5-methylbenzamide
• CAS NO: 1531629-09-0
• Molecular Weight: 347.417
• Mol File: 1531629-09-0.mol

Chemical Properties

• CAS DataBase Reference: N-(quinolin-8-yl)-2-(N-morpholino)-5-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(quinolin-8-yl)-2-(N-morpholino)-5-methylbenzamide(1531629-09-0)
• EPA Substance Registry System: N-(quinolin-8-yl)-2-(N-morpholino)-5-methylbenzamide(1531629-09-0)

Safety Data

• Hazardous Substances Data: 1531629-09-0(Hazardous Substances Data)

Upstream product

• 5765-65-1 4-(benzoyloxy)morpholine 
• 443638-87-7 N-(3-methylbenzoyl)-8-aminoquinoline 
• 99-04-7 m-Toluic acid 
• 1711-06-4 3-Methylbenzoyl chloride 
• 23328-69-0 4-chloromorpholine 

Relevant articles and documents

Electrooxidative amination of sp2 C-H bonds: Coupling of amines with aryl amides via copper catalysis

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp2 C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H2 as the sole and benign byproduct.

Copper-Catalyzed Intermolecular C(sp2)-H Amination with Electrophilic O-Benzoyl Hydroxylamines

A copper-catalyzed intermolecular electrophilic amination of benzamides with O-benzoyl hydroxylamines was achieved with the assistance of an 8-aminoquinolyl group. With this protocol, good compatibility was observed for a variety of aryl amides and hetero

Synthesis method of N-8-quinolyl-2-amino benzamide compound

The invention discloses a synthesis method of an N-8-quinolyl-2-amino benzamide compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: by taking N-8-quinolyl aryl amide as a reaction raw material, cuprous iodide as a catalyst and O-benzoyl hydroxylamine as an amination reagent, carrying out heating reaction in an organic solvent in the presence of inorganic alkali, so as to obtain the N-8-quinolyl-2-amino benzamide compound. The synthesis method is convenient to operate, mild in condition, simple in process, wide in application range of substrate functional groups, good in amination reaction regioselectivity and high in yield.

Synthesis of anthranilic acid derivatives through iron-catalyzed ortho amination of aromatic carboxamides with N-chloroamines

Arenes possessing an 8-quinolinylamide group as a directing group are ortho aminated with N-chloroamines and N-benzoyloxyamines in the presence of an iron/diphosphine catalyst and an organometallic base to produce anthranilic acid derivatives in high yield. The reaction proceeds via iron-catalyzed C-H activation, followed by the reaction of the resulting iron intermediate with N-chloroamine. The choice of the directing group and diphosphine ligand is crucial for obtaining the anthranilic acid derivative with high yield and product selectivity.