153171-96-1Relevant academic research and scientific papers
Dephosphonylation of β-carbonyl phosphonates
Lee, Shi Yong,Lee, Chi-Wan,Oh, Dong Young
, p. 7017 - 7022 (2007/10/03)
A new methodology has been developed for the P-C bond cleavage of β- carbonyl phosphonates. The α,α-disubstituted β-keto phosphonates and the α-carbamoyl phosphonates have been shown to undergo dephosphonylation by reaction of their lithium enolate with LiAlH4, followed by quenching with aqueous H2SO4, affording regioselectively α,α-disubstituted ketone and α-substituted and α,α-disubstituted secondary amides.
Dephosphorylation of α-fully substituted β-keto phosphonates with LiAlH4; regioselective alkylation of ketones employing phosphonate as a temporary activating group
Lee, Shi Yong,Hong, Jong Eoun,Jang, Won Bum,Oh, Dong Young
, p. 4567 - 4570 (2007/10/03)
Alkylation of β-keto phosphonates is performed by treatment of β-keto phosphonates with n-BuLi, followed by addition of alkyl halides. The acquired α-fully substituted β-keto phosphonates are dephosphonylated by treatment of the lithium enolates with LiAlH4, followed by quenching with aqueous H2SO4 solution. This whole procedure represents a new route to regioselective alkylation of ketones.
Phase transfer catalyzed alkylation of 2-(diethoxyphosphinyl)cyclohexanone
Ruder,Kulkarni
, p. 945 - 947 (2007/10/02)
Alkylation of cyclic β-oxophosphonates using the ion pair extractive-phase transfer catalysis method was studied using 2-(diethoxyphosphinyl)cyclohexanone as the model compound. Unlike related phosphonic acid derivatives, the cyclic β-oxophosphonates exhi
