153181-45-4 Usage
Uses
Used in Medicinal Chemistry:
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-one is used as a molecular scaffold for the development of new pharmaceuticals due to its complex structure and multiple functional groups, which can be exploited for various biological activities.
Used in Organic Synthesis:
In the field of organic synthesis, (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-one serves as a versatile intermediate or building block for the synthesis of more complex organic compounds, taking advantage of its multiple reactive sites.
Used in Drug Design:
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-one is used as a lead compound in drug design for potential therapeutic applications, given its unique stereochemistry and functional groups that may interact with biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 153181-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,1,8 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 153181-45:
(8*1)+(7*5)+(6*3)+(5*1)+(4*8)+(3*1)+(2*4)+(1*5)=114
114 % 10 = 4
So 153181-45-4 is a valid CAS Registry Number.
153181-45-4Relevant academic research and scientific papers
Cyclic HIV protease inhibitors: Synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas
Lam, Patrick Y. S.,Ru, Yu,Jadhav, Prabhakar K.,Aldrich, Paul E.,DeLucca, George V.,Eyermann, Charles J.,Chang, Chong-Hwan,Emmett, George,Holler, Edward R.,Daneker, Wayne F.,Li, Liangzhu,Confalone, Pat N.,McHugh, Robert J.,Han, Qi,Li, Renhua,Markwalder, Jay A.,Seitz, Steven P.,Sharpe, Thomas R.,Bacheler, Lee T.,Rayner, Marlene M.,Klabe, Ronald M.,Shum, Linyee,Winslow, Dean L.,Kornhauser, David M.,Jackson, David A.,Erickson-Viitanen, Susan,Hodge, C. Nicholas
, p. 3514 - 3525 (2007/10/03)
High-resolution X-ray structures of the complexes of HIV-1 protease (HIV-1PR) with peptidomimetic inhibitors reveal the presence of a structural water molecule which is hydrogen bonded to both the mobile flaps of the enzyme and the two carbonyls flanking
