153225-91-3Relevant academic research and scientific papers
A Synthesis of (-)-Denopamine
Brown, Roger F. C.,Jackson, W. Roy,McCarthy, Tom D.
, p. 2149 - 2150 (1993)
The important cardiac drug, (-)-denopamine, has been synthesized in 68percent overall yield from para-allyloxybenzaldehyde via (R)-2-hydroxy-2-acetonitrile.
Synthetic applications of optically active cyanohydrins. Enantioselective syntheses of the hydroxyamides tembamide and aegeline, the cardiac drug denopamine, and some analogues of the bronchodilator salbutamol
Brown, Roger F. C.,Donohue, Andrew C.,Roy Jackson,McCarthy, Tom D.
, p. 13739 - 13752 (2007/10/02)
The natural hydroxyamides, (-)-tembamide and (-)-aegeline, and the cardiac drug (-) -denopamine have been prepared in homochiral form in good overall yield (>65%) from para - methoxy or para-allyloxybenzaldehyde by synthetic sequences involving entantioselective hydrocyanation of the aldehydes. Similar chemistry has been used to prepare analogues of the bronchodilator (-)-salbutamol both in high yield and with good enantiomeric excess.
