153230-72-9

Upstream product

• 6559-91-7 4'-demethylepipodophyllotoxin 
• 153230-71-8 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol 
• 153230-70-7 4,4'-bis-O-(dimethyl-tert-butylsilyl)-4'-O-demethylepipodophyllotoxin 
• 1026978-02-8 (5R,5aR,6R,8aR,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole 

Downstream Products

• 1027383-25-0 Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester 
• 153230-73-0 4'-O-carbobenzoxy-4'-O-demethylepipodophyllotoxin 13-methyl ether 

Relevant academic research and scientific papers

Antitumor agents. 144. New γ-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II

The trans-fused γ-lactone ring of etoposide is readily epimerized to its cis epimer, which is biologically inactive, or is metabolized to the inactive ring-opened hydroxy acids. Modification of this γ-lactone ring of 4β- (arylamino)-4'-O-demethyl-4-desoxy