153230-70-7

Upstream product

• 6559-91-7 4'-demethylepipodophyllotoxin 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 642409-76-5 11-oxo-13-deoxo-4'-demethylepipodophyllotoxin 
• 642409-85-6 11-oxo-13-deoxo-4'-benzyloxycarbonyl-4'-demethylepipodophyllotoxin 
• 642409-84-5 5-(tert-butyl-dimethyl-silanyloxy)-9-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 642409-83-4 5-(tert-butyl-dimethyl-silanyloxy)-8-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 642409-81-2 2,2-dimethyl-propionic acid 8-(tert-butyl-dimethyl-silanyloxy)-5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-7-formyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-6-ylmethyl ester 
• 1372118-32-5 4-O-(dimethyl-tert-butylsilyl)-4'-O-demethylepipodophyllotoxin 
• 1026978-02-8 (5R,5aR,6R,8aR,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole 
• 1027383-25-0 Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester 
• 153230-73-0 4'-O-carbobenzoxy-4'-O-demethylepipodophyllotoxin 13-methyl ether 
• 153230-78-5 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylanhydroepipodophyllol 
• 153230-80-9 4β-(4''-fluoroanilino)-4'-O-demethylanhydroepipodophyllol 
• 153230-72-9 4'-O-demethylepipodophyllotoxin β-methyl ether 
• 153230-79-6 4'-O-demethylanhydroepipodophyllol 
• 1027511-04-1 4-((5R,5aR,8aR,9S)-9-Chloro-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of retroetoposide

Retro-4′-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4′-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-β-D- glucoside 26 afforded retroetoposide 5 which is

Antitumor agents. 144. New γ-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II

The trans-fused γ-lactone ring of etoposide is readily epimerized to its cis epimer, which is biologically inactive, or is metabolized to the inactive ring-opened hydroxy acids. Modification of this γ-lactone ring of 4β- (arylamino)-4'-O-demethyl-4-desoxy