153252-44-9 Usage
Uses
Used in Pharmaceutical Industry:
Azido-PEG4-tetra-Ac-beta-D-glucose is used as a PEGylation agent for enhancing the solubility, stability, and bioavailability of therapeutic proteins and drugs. The PEGylation process improves the pharmacokinetic properties of these molecules, reducing their immunogenicity and increasing their half-life in the body.
Used in Drug Delivery Systems:
In the field of drug delivery, Azido-PEG4-tetra-Ac-beta-D-glucose is used as a component in the design of targeted drug delivery systems. The PEG linker can be functionalized through Click Chemistry to attach targeting ligands, enabling the selective delivery of drugs to specific cells or tissues, thereby reducing side effects and increasing therapeutic efficacy.
Used in Bioconjugation:
Azido-PEG4-tetra-Ac-beta-D-glucose is used as a bioconjugation agent to covalently link biological molecules, such as proteins, peptides, or nucleic acids, with other molecules, like fluorescent tags or therapeutic agents. The azide group facilitates the formation of stable bonds through Click Chemistry, allowing for the creation of novel bioconjugates with tailored properties and functions.
Used in Diagnostics:
In the diagnostics industry, Azido-PEG4-tetra-Ac-beta-D-glucose can be employed as a component in the development of imaging agents or biosensors. The PEG linker can improve the stability and solubility of these agents, while the azide group can be used to attach specific targeting moieties or signal-generating molecules through Click Chemistry, enhancing the sensitivity and specificity of diagnostic assays.
Check Digit Verification of cas no
The CAS Registry Mumber 153252-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,2,5 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 153252-44:
(8*1)+(7*5)+(6*3)+(5*2)+(4*5)+(3*2)+(2*4)+(1*4)=109
109 % 10 = 9
So 153252-44-9 is a valid CAS Registry Number.
153252-44-9Relevant academic research and scientific papers
Sasaki,Murahashi,Yamada,Morikawa
, p. 740 - 746 (1995)
We modified the surface of liposomes with galactosyl ligands. At first we determined whether or not the galactosyl moiety was exposed on the liposomes. We then investigated the effect of the ligands on the hepatic accumulation of liposomes in rats. We int
Haoyang, Wei-Wei,Xiao, Qi,Ye, Zhongju,Fu, Yonghong,Zhang, Dan-Wei,Li, Jian,Xiao, Lehui,Li, Zhan-Ting,Hou, Jun-Li
, p. 1097 - 1100 (2021)
A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose-asialoglycoprotein receptor recognition.
A highly versatile convergent/divergent "onion peel" synthetic strategy toward potent multivalent glycodendrimers
Sharma, Rishi,Kottari, Naresh,Chabre, Yoann M.,Abbassi, Le?la,Shiao, Tze Chieh,Roy, René
supporting information, p. 13300 - 13303 (2015/05/20)
Both convergent and divergent strategies for the synthesis of "onion peel" glycodendrimers are reported which resulted in one of the best multivalent ligands known against the virulent factor from a bacterial lectin isolated from Pseudomonas aeruginosa. T
