1532557-35-9

Upstream product

• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 149-30-4 2-Mercaptobenzothiazole 
• 1532557-34-8 2-[(3,5-dimethoxybenzyl)sulfanyl]-1,3-benzothiazole 

Downstream Products

• 18259-14-8 (E)-1-(4'-acetoxyphenyl)-2-(3,5-dimethoxyphenyl)ethene 
• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 
• 80715-09-9 (E)-3,3',5,5'-tetramethoxystilbene 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 94608-23-8 (Z)-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethene 

Relevant academic research and scientific papers

Synthesis of pterostilbene by julia olefination

A simple, E-stereoselective route for the synthesis of the biologically active compounds trans-pterostilbene and tetramethoxy stilbene from the readily available starting materials 3,5-dimethoxy benzyl alcohol and 4-hydroxy benzaldehyde was developed using Julia olefination as a key reaction. Taylor & Francis Group, LLC.

Synthesis of trans-resveratrol using modified Julia olefination route

Bioactive hydroxystilbinoid-trans-resveratrol [(E)-3,5,4′ trihydroxy stilbene, 1] has been synthesized by modified Julia olefination method. The reaction between corresponding carbanion of benzothiazol-2-yl sulfone derivative and p-anisaldehyde dimethyl acetal with sodium hydride as a base, affords mainly cis-3,5,4′ trimethoxystilbene 10b with minor quantity of trans-isomev. Both the isomers have been separated in pure form and confirmed by their NMR spectral data. Demethylation of cis-3,5,4′ trimethoxystilbene either with AlCVpyridine or AlCl3/triethylamine results in the formation of trans-resveratrol.