153261-08-6Relevant academic research and scientific papers
THE POTENTIAL OF PHOSPHINIMINES AS BUILDING BLOCKS FOR A NEW GENERATION OF RADIOPHARMACEUTICALS
Katti, K. V.,Singh, P. R.,Katti, K. K.,Barnes, C. L.,Kopicka, K.,et al.
, p. 55 - 58 (2007/10/02)
Reaction of Ph3P=NSiMe3 with NH4ReO4 produced the ion pair Ph3P+NH2+ReO4- which was characterized by spectroscopic data and X-ray crystallography. The thermolysis of this ion pair gave the neutral Re(VII) complex: Ph3P=N-ReO3 in good yields. The reactions of 99mTcO4- or 188ReO4- with Ph3P=N-SiMe3 also produced the metallic radioisotope analogues of the ion pair: Ph3P=NH2+MO4- (M=99mTc or 188Re) which on heating produce the neutral species Ph3P=N-MO3 (M=99mTc or 188Re). The implications of such small molecule 99mTc or 188Re complexes for the development of a new genre of radiopharmaceuticals will be discussed.
