153274-57-8Relevant articles and documents
Morita-Baylis-Hillman reaction in eutectic solvent under aqueous medium
Zhao, Sanhu,Zhi, Hangyu,Zhang, Mi,Yan, Qin,Fan, Jianfeng,Guo, Jinchang
, p. 62778 - 62784 (2016/07/15)
A series of deep eutectic solvents (DESs) based on choline chloride were prepared and used in the Morita-Baylis-Hillman (M-B-H) reaction. Research showed that the composite solvent (1ChCl/2Gly DES-H2O) is a very effective solvent media for all
Selective hydrogenation of indolizines: An expeditious approach to derive tetrahydroindolizines and indolizidines from Morita-Baylis-Hillman adducts
Teodoro, Bruno V. M.,Correia, José Tiago M.,Coelho, Fernando
, p. 2529 - 2538 (2015/03/18)
In this study, we describe the hydrogenation of indolizines derived from Morita-Baylis-Hillman adducts. We demonstrate that functionalized tetrahydroindolizines and indolizidines can be prepared selectively, at low pressure, by simply adjusting the acidity of the medium. Using this simple and straightforward strategy, substituted tetrahydroindolizines and indolizidines were obtained diastereoselectively in high yield.
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis
Cocco, Mattia,Garella, Davide,Di Stilo, Antonella,Borretto, Emily,Stevanato, Livio,Giorgis, Marta,Marini, Elisabetta,Fantozzi, Roberto,Miglio, Gianluca,Bertinaria, Massimo
, p. 10366 - 10382 (2015/02/19)
Pyroptosis is a caspase-1-dependent pro-inflammatory form of programmed cell death implicated in the pathogenesis of autoinflammatory diseases as well as in disorders characterized by excessive cell death and inflammation. Activation of NLRP3 inflammasome
