15334-22-2

Upstream product

• 142819-91-8 1-(2-benzyloxyphenyl-2-diazopropan-1-one 
• 1199-77-5 α-methylcinnamic acid 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 673-32-5 1-Phenylprop-1-yne 
• 90-02-8 salicylaldehyde 
• 69-72-7 salicylic acid 
• 16635-65-7 (E)-1-(2-hydroxyphenyl)-2-methyl-3-phenyl-2-propen-1-one 

Downstream Products

• 26005-23-2 trans-3-methylflavan 
• 15334-21-1 2,3-dihydro-c-3-hydroxy-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 33902-14-6 c-3-acetoxy-2,3-dihydro-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 116703-71-0 2,3-dihydro-t-3-methyl-r-2-phenyl-c-3-(triphenylphosphoranediylamino)-4-H-1-benzopyran-4-one 
• 116703-60-7 2,3-dihydro-t-mesyloxy-c-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 116703-61-8 c-9b-hydroxy-c-3a-methyl-r-4-phenyl-1,3a,4,9b-tetrahydro<1,2>oxathiolo<5,4-c><1>benzopyran 2,2-dioxide 
• 116703-66-3 c-3-butylamino-2,3-dihydro-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 116703-62-9 3a,4-dihydro-c-3a-methyl-r-4-phenyl<1,2>oxathiolo<4,5-c><1>benzopyran 2,2-dioxide 
• 116703-70-9 c-3-acetamido-2,3-dihydro-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 116703-69-6 c-3-amino-2,3-dihydro-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-one 
• 71972-66-2 3-methyl-2-phenyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Cobalt-Catalyzed Annulation of Salicylaldehydes and Alkynes to Form Chromones and 4-Chromanones

A unique cobalt(I)-diphosphine catalytic system has been identified for the coupling of salicylaldehyde (SA) and an internal alkyne affording a dehydrogenative annulation product (chromone) or a reductive annulation product (4-chromanone) depending on the alkyne substituents. Distinct from related rhodium(I)- and rhodium(III)-catalyzed reactions of SA and alkynes, these annulation reactions feature aldehyde C-H oxidative addition of SA and subsequent hydrometalation of the C=O bond of another SA molecule as common key steps. The reductive annulation to 4-chromanones also involves the action of Zn as a stoichiometric reductant. In addition to these mechanistic features, the CoI catalysis described herein is complementary to the RhI- and RhIII-catalyzed reactions of SA and internal alkynes, particularly in the context of chromone synthesis.

Intermolecular C-O addition of carboxylic acids to arynes

(Figure Presented) A novel, efficient, and expedient route to biologically and pharmaceutically important o-hydroxyaryl ketones, xanthones, 4-chromanones, and flavones has been developed starting from readily available carboxylic acids and commercially available o-(trimethylsilyl)aryl triflates.

Chemoselectivity and stereoselectivity of cyclisation of α-diazocarbonyls leading to oxygen and sulfur heterocycles catalysed by chiral rhodium copper catalysts

Good levels of enantioselectivity have been achieved in intramiolecular C-H insertion reactions of α-diazocarbonyl compounds leading to six-membered oxygen heterocycles (chromanones) through the use of chiral rhodium(II) carboxylates as catalysts.Competition between C-H insertion and sigmatropic rearrangement, the latter leading to five-membered oxygen heterocycles (furanones), was observed with precursors containing a proximal O-allyl side chain.Whereas rhodium carboxylates produced C-H insertion products predominantly, a copper catalyst produced sigmatropic rearrangement products exclusively.A precursor with S-allyl side chain exhibited cyclisation via sigmatropic rearrangement with both copper and rhodium catalyst.

Flavan derivatives useful for impairing RNA virus replication in a cell

A method of treating or preventing viral infections, in particular rhinovirus infections comprising the administration of an effective amount of a flavan derivative of formula (I). STR1 Pharmaceutical compositions containing these compounds, and some nove