1533453-39-2Relevant academic research and scientific papers
Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to allenes: Efficient construction of tertiary and quaternary carbon centers
Li, Changkun,Breit, Bernhard
supporting information, p. 862 - 865 (2014/02/14)
A rhodium-catalyzed chemo- and regioselective intermolecular decarboxylative addition of β-ketoacids to terminal allenes is reported. Using a Rh(I)/DPPF system, tertiary and quaternary carbon centers were formed with exclusively branched selectivity under mild conditions. Preliminary mechanism studies support that the carbon-carbon bond formation precedes the decarboxylation and the reaction occurs in an outer-sphere mechanism.
