153353-99-2Relevant academic research and scientific papers
Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease
Varney,Appelt,Kalish,Reddy,Tatlock,Palmer,Romines,Wu,Musick
, p. 2274 - 2284 (2007/10/02)
The X-ray crystal-structure-based design, synthesis, computational evaluation, and activity of a novel class of HIV protease inhibitors are described. The initial lead compounds 2 and 3 were designed by modeling replacement groups for the C-terminal Val-V
Stereoselective Synthesis of a Hydroxyethylene Dipeptide Isostere
Diederich, Ann M.,Ryckman, David M.
, p. 6169 - 6172 (2007/10/02)
A stereoselective synthesis of a hydroxyethylene dipeptide isostere for Phe-Gly, (4S, 5S)-4-hydroxy-5-amino-6-phenylhexanoic acid, is described.The use of dibenzyl protecting groups on ketoamine 5 accounts for the selectivity on reduction.Also, the dibenzyl group plays a role in directing the introduction of a third chiral center.
