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15291-77-7

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Product FOB Price Min.Order Supply Ability Supplier
E-0008 Ginkgolide B
Cas No: 15291-77-7
No Data 10 Milligram 1 Gram/Week shanghai Tauto Biotech Co., Ltd Contact Supplier
CAS No.15291-77-7 Ginkgolide B CAS NO.15291-77-7
Cas No: 15291-77-7
No Data 1 Kilogram 100 Metric Ton/Month Guangdong Juda Chemical Industrial Co.,Limited Contact Supplier
Ginkgolide B Manufacturer/High quality/Best price/In stock
Cas No: 15291-77-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Ginkgolide B supplier in China
Cas No: 15291-77-7
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
High Content Natural Extract Ginkgolide B HACCP manufacturer
Cas No: 15291-77-7
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
ginkgolide B from ginkgo leaves
Cas No: 15291-77-7
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Ginkgolide B
Cas No: 15291-77-7
No Data No Data / Shanghai Sunwise Chemical Co., Ltd Contact Supplier
Pharmaceutical Grade CAS 15291-77-7 with competitive price
Cas No: 15291-77-7
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Ginkgolide B
Cas No: 15291-77-7
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier
ISO Kosher Certified Ginkgo Biloba Ginkgo Biloba Leaf Extract for Heart Health.
Cas No: 15291-77-7
USD $ 1.0-10.0 / Gram 1 Gram 200 Metric Ton/Day Hebei Nengqian Chemical Import and Export Co., LTD Contact Supplier

15291-77-7 Usage

Uses

Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references

Uses

Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists

Chemical Properties

White Crystalline Solid

Biological Activity

Platelet-activating factor (PAF) receptor antagonist (K i = 1.3 μ M). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo .

15291-77-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (94970)  GinkgolideB  analytical standard 15291-77-7 94970-10MG 2,046.33CNY Detail
Sigma (G6910)  GinkgolideBfromGinkgobilobaleaves  ≥90% (HPLC) 15291-77-7 G6910-10MG 1,132.56CNY Detail
Sigma (G6910)  GinkgolideBfromGinkgobilobaleaves  ≥90% (HPLC) 15291-77-7 G6910-50MG 3,935.88CNY Detail

15291-77-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Ginkgolide B

1.2 Other means of identification

Product number -
Other names Ginkgolide?B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15291-77-7 SDS

15291-77-7Synthetic route

α-benzylginkgolide B
170288-58-1

α-benzylginkgolide B

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 2888 Torr; for 24h;97%
1-O-(tert-Butyldiphenylsilyl)ginkgolid B
130523-06-7

1-O-(tert-Butyldiphenylsilyl)ginkgolid B

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h;73%
C28H32O11
145473-36-5

C28H32O11

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol at 23℃; under 760 Torr; for 5h; Yield given;
7-trifluoromethanesulfonyloxy ginkgolide B
173102-79-9

7-trifluoromethanesulfonyloxy ginkgolide B

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
With tetrabutylammonium borohydride
1,3,7,10-Tetrahydroxyginkgolid
15291-76-6

1,3,7,10-Tetrahydroxyginkgolid

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: nBu4NBH4
View Scheme
ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: diisopropylethylamine / acetonitrile / 5 h / 0 °C
2: 63 percent / 4-N,N-dimethylaminopyridine / acetonitrile / 12 h / 5 °C
3: tri-n-butyltin hydride, bisazoisobutyronitrile / benzene / 12 h / Heating
4: H2 / Pd-C / methanol / 5 h / 23 °C / 760 Torr
View Scheme
C28H32O12
145497-37-6

C28H32O12

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 63 percent / 4-N,N-dimethylaminopyridine / acetonitrile / 12 h / 5 °C
2: tri-n-butyltin hydride, bisazoisobutyronitrile / benzene / 12 h / Heating
3: H2 / Pd-C / methanol / 5 h / 23 °C / 760 Torr
View Scheme
C35H31F5O13S
145497-38-7

C35H31F5O13S

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tri-n-butyltin hydride, bisazoisobutyronitrile / benzene / 12 h / Heating
2: H2 / Pd-C / methanol / 5 h / 23 °C / 760 Torr
View Scheme
Ginkgolide C
15291-76-6

Ginkgolide C

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / imidazole / dimethylformamide / 48 h
2: 66 percent / DMAP / acetonitrile / 24 h
3: 93 percent / tributyltin hydride, AIBN / toluene / 3 h / Heating
4: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h
View Scheme
1-O-(tert-Butyldiphenylsilyl)ginkgolid C
130523-04-5

1-O-(tert-Butyldiphenylsilyl)ginkgolid C

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 66 percent / DMAP / acetonitrile / 24 h
2: 93 percent / tributyltin hydride, AIBN / toluene / 3 h / Heating
3: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h
View Scheme
1-O-(tert-Butyldiphenylsilyl)-7-O-(phenyloxythiocarbonyl)ginkgolid C
130523-05-6

1-O-(tert-Butyldiphenylsilyl)-7-O-(phenyloxythiocarbonyl)ginkgolid C

ginkgolide B
15291-77-7

ginkgolide B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / tributyltin hydride, AIBN / toluene / 3 h / Heating
2: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h
View Scheme
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

ginkgolide B
15291-77-7

ginkgolide B

10-O-p-chlorobenzylginkgolide B

10-O-p-chlorobenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;98.3%
ginkgolide B
15291-77-7

ginkgolide B

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

1-(tert-butyldiphenylsilyloxy)-3,10-dihydroxyginkgolid
130523-06-7

1-(tert-butyldiphenylsilyloxy)-3,10-dihydroxyginkgolid

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 48h; Ambient temperature;98%
ginkgolide B
15291-77-7

ginkgolide B

1-chloromethyl-4-fluorobenzene
352-11-4

1-chloromethyl-4-fluorobenzene

10-O-p-fluorobenzylginkgolide B

10-O-p-fluorobenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;96.7%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

ginkgolide B
15291-77-7

ginkgolide B

10-O-(2-dimethylaminoethyl)ginkgolide B
914251-20-0

10-O-(2-dimethylaminoethyl)ginkgolide B

Conditions
ConditionsYield
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; Reagent/catalyst; Temperature; Flow reactor;94.1%
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; for 0.05h; Reagent/catalyst; Temperature; Concentration; Flow reactor;94.1%
4-nitrobenzyl chloride
100-14-1

4-nitrobenzyl chloride

ginkgolide B
15291-77-7

ginkgolide B

10-O-p-nitrobenzylginkgolide B

10-O-p-nitrobenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;92.3%
ginkgolide B
15291-77-7

ginkgolide B

2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

10-O-p-methoxyphenacylginkgolide B

10-O-p-methoxyphenacylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;90.1%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

ginkgolide B
15291-77-7

ginkgolide B

10-O-ethoxycarbonylginkgolide B

10-O-ethoxycarbonylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Acylation; Heating;89.4%
ginkgolide B
15291-77-7

ginkgolide B

1-chloroacetophenone
532-27-4

1-chloroacetophenone

10-O-phenacylginkgolide B

10-O-phenacylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;89.2%
1-hydroxybenzotriazolyl acetate
18355-05-0

1-hydroxybenzotriazolyl acetate

ginkgolide B
15291-77-7

ginkgolide B

A

C20H24O10(CH2CO)

C20H24O10(CH2CO)

B

C20H24O10(CH2CO)

C20H24O10(CH2CO)

Conditions
ConditionsYield
With pyridine; dmap In N,N-dimethyl-formamideA 88%
B 9%
ginkgolide B
15291-77-7

ginkgolide B

allyl bromide
106-95-6

allyl bromide

10-O-allylginkgolide B
289490-32-0

10-O-allylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;87.8%
N-methyl-2-chloroethylamine hydrochloride
4535-90-4

N-methyl-2-chloroethylamine hydrochloride

ginkgolide B
15291-77-7

ginkgolide B

10-O-methylaminoethyl ginkgolide B
914251-23-3

10-O-methylaminoethyl ginkgolide B

Conditions
ConditionsYield
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; Flow reactor;83.5%
2-chloroethanamine hydrochloride
870-24-6

2-chloroethanamine hydrochloride

ginkgolide B
15291-77-7

ginkgolide B

10-O-aminoethyl ginkgolide B

10-O-aminoethyl ginkgolide B

Conditions
ConditionsYield
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; Flow reactor;79.4%
ginkgolide B
15291-77-7

ginkgolide B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

10-O-ethyloxycarbonylmethylginkgolide B

10-O-ethyloxycarbonylmethylginkgolide B

B

1-O-ethyloxycarbonylmethylginkgolide B

1-O-ethyloxycarbonylmethylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;A 78.3%
B 12.1%
ginkgolide B
15291-77-7

ginkgolide B

2-chloro-ethanol
107-07-3

2-chloro-ethanol

10-O-hydroxyethyl ginkgolide B

10-O-hydroxyethyl ginkgolide B

Conditions
ConditionsYield
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; Flow reactor;76.3%
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; for 0.05h; Flow reactor;76.3%
4-bromobut-2-enenitrile
42879-03-8

4-bromobut-2-enenitrile

ginkgolide B
15291-77-7

ginkgolide B

10-O-(3-cyanoallyl)ginkgolide B

10-O-(3-cyanoallyl)ginkgolide B

Conditions
ConditionsYield
With triethylamine; potassium iodide In chloroform Reflux;75%
ginkgolide B
15291-77-7

ginkgolide B

4-Methylbenzyl bromide
104-81-4

4-Methylbenzyl bromide

10-O-p-methylbenzylginkgolide B
170288-73-0

10-O-p-methylbenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 75℃; for 0.75h;72.9%
1-bromomethyl-4-iodobenzene
16004-15-2

1-bromomethyl-4-iodobenzene

ginkgolide B
15291-77-7

ginkgolide B

10-O-p-iodobenzylginkgolide B
170289-24-4

10-O-p-iodobenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 70℃; for 0.666667h;72.4%
ginkgolide B
15291-77-7

ginkgolide B

2-bromopropionitrile
19481-82-4

2-bromopropionitrile

10-O-(1-cyanoethyl)ginkgolide B

10-O-(1-cyanoethyl)ginkgolide B

Conditions
ConditionsYield
With triethylamine; potassium iodide In chloroform Reflux;71%
benzyl chloride
100-44-7

benzyl chloride

ginkgolide B
15291-77-7

ginkgolide B

α-benzylginkgolide B
170288-58-1

α-benzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;65.3%
ginkgolide B
15291-77-7

ginkgolide B

propargyl bromide
106-96-7

propargyl bromide

10-O-propargylated ginkgolide B

10-O-propargylated ginkgolide B

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux; Inert atmosphere;65%
With potassium carbonate; potassium iodide In acetonitrile at 100℃; for 2.5h;
ginkgolide B
15291-77-7

ginkgolide B

1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

10-O-p-bromobenzylginkgolide B
170289-51-7

10-O-p-bromobenzylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 70℃; for 0.833333h;64.5%
formaldehyd
50-00-0

formaldehyd

ginkgolide B
15291-77-7

ginkgolide B

1,10-O,O-methyleneginkgolide B

1,10-O,O-methyleneginkgolide B

Conditions
ConditionsYield
With sulfuric acid; acetic acid In tetrahydrofuran for 8h; Condensation; Heating;61.8%
3,5-dinitrobenzoic acid
99-34-3

3,5-dinitrobenzoic acid

ginkgolide B
15291-77-7

ginkgolide B

C27H26N2O15

C27H26N2O15

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 6h;61.25%
ginkgolide B
15291-77-7

ginkgolide B

methyl iodide
74-88-4

methyl iodide

A

1-O-methylginkgolide B

1-O-methylginkgolide B

B

10-O-methylginkgolide B

10-O-methylginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 0.5h; Alkylation; Heating;A 26.7%
B 60.1%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

ginkgolide B
15291-77-7

ginkgolide B

10-O-(tert-butoxyformylmethyl)ginkgolide B

10-O-(tert-butoxyformylmethyl)ginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran for 2h; Reflux;58%
ginkgolide B
15291-77-7

ginkgolide B

methyl 2-(2-iodoethoxy)acetate
84424-42-0

methyl 2-(2-iodoethoxy)acetate

10-O-(methoxyformylmethoxyethyl)ginkgolide B

10-O-(methoxyformylmethoxyethyl)ginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran for 2h; Reflux;58%
methyl bromoethoxyethoxyacetate

methyl bromoethoxyethoxyacetate

ginkgolide B
15291-77-7

ginkgolide B

10-O-(methoxyformylmethoxyethoxyethyl)ginkgolide B

10-O-(methoxyformylmethoxyethoxyethyl)ginkgolide B

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran for 2h; Reflux;56%
ginkgolide B
15291-77-7

ginkgolide B

4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

A

C28H30O12

C28H30O12

B

C28H30O12

C28H30O12

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 6h;A 8.4%
B 55.57%

15291-77-7Related news

Ginkgolide B (cas 15291-77-7) and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates08/04/2019

The accumulation of aggregated forms of the α-Synuclein (α-Syn) is associated with the pathogenesis of Parkinson's disease (PD), a chronic progressive neurodegenerative disorder. Extensive evidences have shown the promising effects of Ginkgo biloba consumption on motor activity after PD. ...detailed

Ginkgolide B (cas 15291-77-7) enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway08/03/2019

Gemcitabine resistance will occur by time after the initial response in pancreatic cancer. Ginkgolide B (GB), a major terpene lactone component of Ginkgo biloba leaves, is a highly selective and competitive inhibitor for platelet-activating factor (PAF) receptor. In the present study, we evaluat...detailed

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