153387-53-2Relevant academic research and scientific papers
Design, synthesis and photoswitching of broad-spectrum fluorescent hexaarylbiimidazoles
Gong, Wen-Liang,Xiong, Zu-Jing,Li, Chong,Zhu, Ming-Qiang
, p. 64371 - 64378 (2014)
A series of novel hexaarylbiimidazole (HABI)-containing fluorophores with broad-spectrum emissions ranging from blue, green and red emissions, have been designed and synthesized. Their photochromism and fluorescence switching properties are investigated by UV-Vis absorption and fluorescence spectra in solutions and PMMA films. By connecting carbazole (Cz), naphthalimide (NI) and perylene-mono-imide (PMI) to HABI with a spacer, three molecular photoswitches with broad-spectrum fluorescence varying from deep blue (Cz-O-HABI, λem = 390 nm, ΦF = 0.27), green (NI-O-HABI, λem = 490 nm, ΦF = 0.25) to far red (PMI-O-HABI, λem = 650 nm, ΦF = 0.25) have been obtained. The "ON"/"OFF" ratios are calculated to be about 8.9, 8.0 and 3.7 (calculated from FL spectra) for Cz-O-HABI, NI-O-HABI and PMI-O-HABI, respectively. Such a series of photoswitchable fluorophores constitute prototypes of a photochromic molecular library in which fluorescence resonance energy transfer can be reversibly modulated by an external stimulus, namely, UV light.
CoA-IT and PAF inhibitors
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, (2008/06/13)
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
