1752-94-9

Basic information

• Product Name: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*
• Synonyms: 2-(4-Hydroxyphenyl)-4,5-diphenylimidazol;4-(4,5-Diphenyl-1H-iMidazol-2-yl)phenol [for BiocheMical Research];2-(4-Hydroxyphenyl)-4,5-diphenyl-1H-imidazole;NSC 525164;NSC 683642;Phenol,4-(4,5-diphenyl-1H-imidazol-2-yl)-
• CAS NO: 1752-94-9
• Molecular Formula: C₂₁H₁₆N₂O
• Molecular Weight: 312.36
• Mol File: 1752-94-9.mol
• Article Data: 118

Chemical Properties

• Melting Point: 270-272℃ (ethanol )
• Boiling Point: 491.9°C at 760 mmHg
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 8.05E-10mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(1752-94-9)
• EPA Substance Registry System: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(1752-94-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 1752-94-9(Hazardous Substances Data)

Usage

Uses

Chemiluminescence: suitable as amplifier for 3-aminophthalhyrazide (Luminol).

InChI:InChI=1/C21H16N2O/c24-18-13-11-17(12-14-18)21-22-19(15-7-3-1-4-8-15)20(23-21)16-9-5-2-6-10-16/h1-14,22-23H

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 134-81-6 benzil 
• 631-61-8 ammonium acetate 
• 95-54-5 1,2-diamino-benzene 
• 264889-14-7 (4-(4,5-diphenyl-1H-imidazol-2-yl)-phenyl)boronic acid 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 57-13-6 urea 
• 5173-27-3 1,2-bis(4-hydroxyphenyl)-ethane-1,2-diol 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100025-57-8 4-(5,6-diphenyl-1,2,4-triazin-3-yl)phenol 
• 64-19-7 acetic acid 

Downstream Products

• 153387-53-2 2-(4-octyloxyphenyl)-4,5-diphenylimidazole 
• 1387542-23-5 4-[4-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy]phthalonitrile 
• 908261-13-2 4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl acrylate 
• 150417-60-0 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)phenyl acetate 
• 362595-04-8 1-benzyl-2-(4-hydroxyphenyl)-4,5-diphenyl-1H-imidazole 
• 484-47-9 lophine 

Relevant articles and documents

One-Pot Synthesis of 2,4,5-Triphenyl Imidazoles from 1,2-Diols as Key Reagents

A simple one-pot procedure for the preparation of 2,4,5-triphenyl imidazole derivatives is presented. The procedure involves the lead tetraacetate oxidation of 1,2-diols to give aldehydes in situ, which then undergo a three-component reaction with benzil and ammonium acetate to yield the imidazole derivatives.

Synthesis and characterization of a new polymeric catalyst and used for the synthesis of imidazole derivatives

Cross-linked poly (4-vinylpyridine) supported TiCl4 abbreviated as [P4-VP]-Ti(IV) as a new polymeric catalyst was easily prepared and characterized by using the X-ray spectroscopy, EDS, mapping, TGA/DTG and FTIR techniques. This catalyst was used for synthesis of imidazole derivatives via one-pot three-component condensation reaction of benzil, ammonium acetate and aldehydes. This protocol offers advantages such as short reaction time, simple reaction work-up with reusability of catalyst. Graphic abstract: [Figure not available: see fulltext.].

Homoselective synthesis of 5-substituted 1H-tetrazoles and one-pot synthesis of 2,4,5-trisubstuted imidazole compounds using BNPs@SiO2-TPPTSA as a stable and new reusable nanocatalyst

Considering the importance of tetrazole and imidazole derivatives in pharmacy, industry, and explosives, BNPs@SiO2-TPPTSA was easily prepared and used as an effective, stable, and renewable nanocatalyst for the homoselective synthesis of different 5-substituted 1H-tetrazoles and atom economic synthesis of 2,4,5-trisubstituted-1H-imidazoles in solventless conditions. BNPs@SiO2-TPPTSA was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), thermal gravimetric-differential thermal analysis (TGA-DTA), mapping, pH analysis, and Fourier transform infrared (FT-IR) techniques. Furthermore, the catalyst recycled for at least sequential five loads without a remarkable drop-in catalytic activity.

A green and simple method for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives using acidic ionic liquid as an effective and recyclable catalyst under ultrasound

Abstract: In the current work, an acidic ionic liquid ([{(IMC)-4-OMBH}BIM][HSO4]3) has been utilized as an effective and recyclable catalyst for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives with high yields under optimal reaction conditions and ultrasound irradiation. Important features of the new catalyst are facile synthesis, cheap reagents and successful reuse for many times. What makes the present method an effective contribution in the field of synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives is the fact that it can be described as environmentally friendly, economical, short reaction time, possible recover of the catalyst, simple workup, safer and mild reaction conditions. Graphic abstract: [Figure not available: see fulltext.].