1752-94-9

Basic information

• Product Name: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*
• Synonyms: 2-(4-Hydroxyphenyl)-4,5-diphenylimidazol;4-(4,5-Diphenyl-1H-iMidazol-2-yl)phenol [for BiocheMical Research];2-(4-Hydroxyphenyl)-4,5-diphenyl-1H-imidazole;NSC 525164;NSC 683642;Phenol,4-(4,5-diphenyl-1H-imidazol-2-yl)-
• CAS NO: 1752-94-9
• Molecular Formula: C₂₁H₁₆N₂O
• Molecular Weight: 312.36
• Mol File: 1752-94-9.mol
• Article Data: 118

Chemical Properties

• Melting Point: 270-272℃ (ethanol )
• Boiling Point: 491.9°C at 760 mmHg
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 8.05E-10mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(1752-94-9)
• EPA Substance Registry System: 4-(4 5-DIPHENYL-2-IMIDAZOLYL)PHENOL*(1752-94-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 1752-94-9(Hazardous Substances Data)

Usage

Uses

Chemiluminescence: suitable as amplifier for 3-aminophthalhyrazide (Luminol).

InChI:InChI=1/C21H16N2O/c24-18-13-11-17(12-14-18)21-22-19(15-7-3-1-4-8-15)20(23-21)16-9-5-2-6-10-16/h1-14,22-23H

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 264889-14-7 (4-(4,5-diphenyl-1H-imidazol-2-yl)-phenyl)boronic acid 
• 631-61-8 ammonium acetate 
• 134-81-6 benzil 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 57-13-6 urea 
• 5173-27-3 1,2-bis(4-hydroxyphenyl)-ethane-1,2-diol 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100025-57-8 4-(5,6-diphenyl-1,2,4-triazin-3-yl)phenol 
• 64-19-7 acetic acid 

Downstream Products

• 150417-60-0 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)phenyl acetate 
• 908261-13-2 4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl acrylate 
• 1387542-23-5 4-[4-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy]phthalonitrile 
• 153387-53-2 2-(4-octyloxyphenyl)-4,5-diphenylimidazole 
• 362595-04-8 1-benzyl-2-(4-hydroxyphenyl)-4,5-diphenyl-1H-imidazole 
• 484-47-9 lophine 

Relevant articles and documents

One-Pot Synthesis of 2,4,5-Triphenyl Imidazoles from 1,2-Diols as Key Reagents

A simple one-pot procedure for the preparation of 2,4,5-triphenyl imidazole derivatives is presented. The procedure involves the lead tetraacetate oxidation of 1,2-diols to give aldehydes in situ, which then undergo a three-component reaction with benzil and ammonium acetate to yield the imidazole derivatives.

Homoselective synthesis of 5-substituted 1H-tetrazoles and one-pot synthesis of 2,4,5-trisubstuted imidazole compounds using BNPs@SiO2-TPPTSA as a stable and new reusable nanocatalyst

Considering the importance of tetrazole and imidazole derivatives in pharmacy, industry, and explosives, BNPs@SiO2-TPPTSA was easily prepared and used as an effective, stable, and renewable nanocatalyst for the homoselective synthesis of different 5-substituted 1H-tetrazoles and atom economic synthesis of 2,4,5-trisubstituted-1H-imidazoles in solventless conditions. BNPs@SiO2-TPPTSA was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), thermal gravimetric-differential thermal analysis (TGA-DTA), mapping, pH analysis, and Fourier transform infrared (FT-IR) techniques. Furthermore, the catalyst recycled for at least sequential five loads without a remarkable drop-in catalytic activity.

A green and simple method for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives using acidic ionic liquid as an effective and recyclable catalyst under ultrasound

Abstract: In the current work, an acidic ionic liquid ([{(IMC)-4-OMBH}BIM][HSO4]3) has been utilized as an effective and recyclable catalyst for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives with high yields under optimal reaction conditions and ultrasound irradiation. Important features of the new catalyst are facile synthesis, cheap reagents and successful reuse for many times. What makes the present method an effective contribution in the field of synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives is the fact that it can be described as environmentally friendly, economical, short reaction time, possible recover of the catalyst, simple workup, safer and mild reaction conditions. Graphic abstract: [Figure not available: see fulltext.].

One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1H-imidazoles Using Mn2+Complex of [7-Hydroxy-4-methyl-8-coumarinyl] Glycine as a Heterogeneous Catalyst

A highly efficient and simple synthesis of 2,4,5-trisubstituted imidazoles has been developed using highly reusable support‐free Mn2+complex of [7-hydroxy-4-methyl-8-coumarinyl] glycine as a heterogeneous catalyst via a one-pot three-component reaction of benzil, aldehydes and ammonium acetate as a nitrogen source. Moreover, this catalyst was characterized by various techniques such as field emission scanning electron microscope (FE-SEM), energy dispersive X-ray spectroscopy (EDX), FT-IR spectroscopy, powder X-ray diffraction (XRD), inductively coupled plasma (ICP) and thermal gravimetric analysis (TGA). Also, the catalyst is stable and could be reused for at least six times without significant loss of activity. Graphic Abstract: [Figure not available: see fulltext.]