153387-87-2Relevant academic research and scientific papers
An alternative isoxazole route to α-alkoxycarbonyl-β-diketones
Jones, Raymond C. F.,Dunn, Stephen H.,Duller, Kathryn A. M.
, p. 1319 - 1321 (2007/10/03)
Cycloaddition of oxygen-functionalized nitrite oxides to the enamine from ethyl acetoacetate produces 4-ethoxycarbonyl-5-methylisoxazoles carrying a 3-tetrahydropyranyloxymethyl, 3-diethoxymethyl or 3-ethoxycarbonyl substituent; the 3-formylisoxazole is prepared from the former two and condensed in situ with phosphoranes to give 3-alkenylisoxazoles that are cleaved by hexacarbonylmolybdenum or hydrogenolysis to afford α-alkoxycarbonyl-β-diketones.
An Isoxazole Route to Unsaturated α-Alkoxycarbonyl-β-diketones
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.
, p. 1715 - 1716 (2007/10/02)
Cycloaddition of diethylphosphonomethyl nitrile oxide to the enamine from ethyl acetoacetate produces 4-ethoxycarbonyl-3-diethoxyphosphonylmethyl-5-methylisoxazole; condensation of the phosphonate with aldehydes and ketones gives 3-alkenylisoxazoles that are cleaved by hexacarbonylmolybdenum to afford unsaturated α-alkoxycarbonyl-β-diketones.
