153403-54-4Relevant academic research and scientific papers
N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
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, (2010/12/29)
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists
Yamazaki, Yukiyoshi,Abe, Kazutoyo,Toma, Tsutomu,Nishikawa, Masahiro,Ozawa, Hidefumi,Okuda, Ayumu,Araki, Takaaki,Oda, Soichi,Inoue, Keisuke,Shibuya, Kimiyuki,Staels, Bart,Fruchart, Jean-Charles
, p. 4689 - 4693 (2008/02/11)
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure-activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.
AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS
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, (2008/06/13)
Compounds useful in the preparation of pharmaceutical preparations for the treatment of microbial infection where such compounds are of structural Formula I I or pharmaceutically acceptable salts thereof wherein: R1 is -CHO, -COCH3, -COCHCl2, -COCHF2, -CO2CH3, -SO2CH3, or -COCH2OH; X1 and X2 are independently H, F, or Cl; and Q is a five membered ting heterocycle (azolyl ring) of the general form: wherein A, B, and C are independently oxygen (O), nitrogen (N), sulfur (S) or Carbon (C). In all cases, the piperazine nitrogen atom is attached at the carbon atom of the carbon-nitrogen double bond.
Azolyl piperazinyl phenyl oxazolidinone antimicrobials
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, (2008/06/13)
Compounds useful in the preparation of pharmaceutical preparations for the treatment of microbial infection where such compounds are of structural Formula I STR1 or pharmaceutically acceptable salts thereof wherein: R1 is --CHO, --COCH3, --COCHCl2, --COCHF2, --CO2 CH3, --SO2 CH3, or --COCH2 OH; X1 and X2 are independently H, F, or Cl; and Q is a five membered ting heterocycle (azolyl ring) of the general form: STR2 wherein A, B, and C are independently oxygen (O), nitrogen (N), sulfur (S) or Carbon (C). In all cases, the piperazine nitrogen atom is attached at the carbon atom of the carbon-nitrogen double bond.
