53981-25-2

Basic information

• Product Name: 6-Fluoro-2-aminophenol
• Synonyms: 6-Fluoro-2-Aminophenol;6-Fluoro-2-aminophen;3-Fluoro-2-hydroxyaniline 97%;2-Amino-6-fluorophenol 97%;2-Amino-6-fluorophenol97%
• CAS NO: 53981-25-2
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.12
• Product Categories: Aromatics;Metabolites & Impurities
• Mol File: 53981-25-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 215.7 °C at 760 mmHg
• Flash Point: 84.2 °C
• Appearance: /Solid
• Density: 1.347g/cm³
• Vapor Pressure: 0.0996mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.50±0.10(Predicted)
• CAS DataBase Reference: 6-Fluoro-2-aminophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-2-aminophenol(53981-25-2)
• EPA Substance Registry System: 6-Fluoro-2-aminophenol(53981-25-2)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 53981-25-2(Hazardous Substances Data)

Usage

Chemical Properties

Purple crystals

Uses

A metabolite of halogenated aniline.

InChI:InChI=1/C6H6FNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2

Upstream product

• 1526-17-6 2-fluoro-6-nitrophenol 

Relevant articles and documents

COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a compound having a ZNF143 inhibitory activity as well as to provide a ZNF143 inhibitory agent and pharmaceutical composition containing the same. SOLUTION: Provided is a compound represented by formula (I) or a salt thereof as well as a ZNF143 inhibitory agent containing the same and a pharmaceutical composition having the same as an active ingredient. A-B-C-D (I)[A is H, a methyl group, a naphthyl group, a phenyl group or a nitrogen-containing heterocyclic ring; B is as shown below, and C is an amide bond or a heteroaromatic ring containing N and O; D is a substituted/unsubstituted phenyl group or a monocyclic heteroaromatic ring containing N or S; and C and D are both fused heterocyclic ring or the like optionally having a substituent group.]. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

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The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.