15341-69-2Relevant articles and documents
NEW BRADYKININ B1 ANTAGONISTS
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Page/Page column 127, (2010/04/03)
The invention relates to compounds of formula (I) where in R1, R1a, R1b, R2, R3 and X, X1, X2, X3 have the meaning as cited in the description and the claims. Said compounds are useful as Bradykinin B1 antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
Facile synthesis of methyl 2-formyl-5-hydroxymethyl-3-furancarboxylate
Toro, Andras,Deslongchamps, Pierre
, p. 2317 - 2321 (2007/10/03)
A short practical synthesis of the title trisubstituted furan is presented. It involves a high yield Knoevenagel condensation of glyceraldehyde and methyl acetoacetate to the furan nucleus and, following a protection of the furyl alcohol, a radical bromin