81661-26-9

Basic information

• Product Name: METHYL 5-FORMYL-2-METHYL-3-FUROATE
• Synonyms: METHYL 5-FORMYL-2-METHYL-3-FUROATE;3-Furancarboxylicacid, 5-forMyl-2-Methyl-, Methyl ester;methyl 5-formyl-2-methylfuran-3-carboxylate
• CAS NO: 81661-26-9
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• Mol File: 81661-26-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 275.2°C at 760 mmHg
• Flash Point: 120.2°C
• Appearance: /
• Density: 1.217g/cm³
• Vapor Pressure: 0.00516mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: METHYL 5-FORMYL-2-METHYL-3-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-FORMYL-2-METHYL-3-FUROATE(81661-26-9)
• EPA Substance Registry System: METHYL 5-FORMYL-2-METHYL-3-FUROATE(81661-26-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 81661-26-9(Hazardous Substances Data)

Usage

General Description

Methyl 5-formyl-2-methyl-3-furoate is a compound with the chemical formula C7H8O4. It is a derivative of furan and is commonly used in organic synthesis and as a flavoring agent in the food industry due to its pleasant fruity odor. This chemical is also known for its potential application in the production of pharmaceuticals and agrochemicals. It has been studied for its antioxidant and antimicrobial properties, making it a promising candidate for various industrial and commercial applications. Additionally, methyl 5-formyl-2-methyl-3-furoate is considered to be relatively safe for use, with minimal reported toxicity.

InChI:InChI=1/C8H8O4/c1-5-7(8(10)11-2)3-6(4-9)12-5/h3-4H,1-2H3

Upstream product

• 15341-69-2 5-hydroxymethyl-2-methyl-3-methoxycarbonylfuran 
• 6141-58-8 methyl 2-methyl-3-furancarboxylate 
• 28921-35-9 2-methyl-3-ethoxycarbonyl-furan 
• 68-12-2 N,N-dimethyl-formamide 
• 105-45-3 acetoacetic acid methyl ester 
• 17651-08-0 methyl 5-(D-arabino-tetroxybutyl)-2-methyl-3-furoate 

Downstream Products

• 1398110-62-7 cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide 
• 1398110-65-0 C-{2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-yl}methylamine 
• 1398110-64-9 {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}carbamic acid tert-butyl ester 
• 1398110-94-5 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde 
• 1398110-93-4 {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]furan-3-yl}methanol 
• 1398110-92-3 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-carboxylic acid methyl ester 
• 1398110-91-2 (E/Z)-2-methyl-5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]furan-3-carboxylic acid methyl ester 
• 1398110-90-1 2-methyl-5-[4,4,4-trifluoro-3-hydroxy-3-(3,4,5-trichlorophenyl)butyryl]furan-3-carboxylic acid methyl ester 
• 1398110-63-8 tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide 
• 15341-69-2 5-hydroxymethyl-2-methyl-3-methoxycarbonylfuran 

Relevant articles and documents

Synthesis and properties of (1,3-dioxolan-2-yl)furans

Reaction of formylfurancarboxylates with excess ethylene glycol in the presence of p-toluenesulfonic acid gives rise to (1,3-dioxolan-2-yl)furancarboxylates. Reduction of these products with lithium aluminum hydride proceeds with preservation of the dioxolane ring. Except for 5-(1,3-dioxolan-2-yl)(hydroxymethyl)-2-methyl-3-furan, the obtained alcohols are unstable. Chlorides derived from them decompose under conditions of the Michaelis-Becker reaction, and no phosphorylation products are formed. By contrast, the above-mentioned stable alcohol by treatment with thionyl chloride in the presence of pyridine is converted to a fairly stable chloromethylfuran. The latter compound reacts with sodium diethyl phosphite in benzene to form the corresponding phosphonate that exists as a 1:4 mixture of two spectroscopically discernible conformers.

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

ISOXAZOLE DERIVATIVES

The invention relates to new isoxazoline compounds of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (1