153433-81-9Relevant academic research and scientific papers
Chemo- and biocatalytic strategies to obtain phenylisoserine, a lateral chain of Taxol by asymmetric reduction
Rimoldi, Isabella,Pellizzoni, Michela,Facchetti, Giorgio,Molinari, Francesco,Zerla, Daniele,Gandolfi, Raffaella
experimental part, p. 2110 - 2116 (2012/03/27)
Enriched ethyl 3-benzamido-2-hydroxy-3-phenylpropanoate (protected phenylisoserine), the chiral side chain of Taxol, was obtained via asymmetric reduction with transition metal-diphoshine complexes or with whole cells of non-conventional yeasts. Asymmetri
Enantiodivergent, biocatalytic routes to both taxol side chain antipodes
Feske, Brent D.,Kaluzna, Iwona A.,Stewart, Jon D.
, p. 9654 - 9657 (2007/10/03)
Two enantiocomplementary bakers' yeast enzymes reduced an α-chloro-β-keto ester to yield precursors for both enantiomers of the N-benzoyl phenylisoserine Taxol side chain. After base-mediated ring closure of the chlorohydrin enantiomers, the epoxides were
Synthesis of Four Chiral Pharmaceutical Intermediates by Biocatalysis
Patel, Ramesh N.,Banerjee, Amit,Szarka, Laszlo J.
, p. 1247 - 1264 (2007/10/03)
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates.These include: (i) the microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic ethyl ester to (3S,5R)-dihydroxy-6-(benzyloxy) he
