153433-79-5Relevant academic research and scientific papers
Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
-
, (2008/06/13)
Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.
Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
-
, (2008/06/13)
An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
Microbial Synthesis of (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester-a taxol side-chain synthon
Patel, Ramesh N.,Banerjee, Amit,Howell, Jeffrey M.,McNamee, Clyde G.,Brozozowski, David,et al.
, p. 2069 - 2084 (2007/10/02)
The chiral intermediate (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester 2a, a potential taxol 5 side-chain synthon, was prepared by microbial and enzymatic processes.Taxol 5, is an anticancer compound recently approved by FDA for the treatment of ova
