153436-03-4Relevant academic research and scientific papers
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site
Di Fabio, Romano,Capelli, Anna M.,Conti, Nadia,Cugola, Alfredo,Donati, Daniele,Feriani, Aldo,Gastaldi, Paola,Gaviraghi, Giovanni,Hewkin, Cheryl T.,Micheli, Fabrizio,Missio, Andrea,Mugnaini, Manolo,Pecunioso, Angelo,Quaglia, Anna M.,Ratti, Emiliangelo,Rossi, Luciana,Tedesco, Giovanna,Trist, David G.,Reggiani, Angelo
, p. 841 - 850 (2007/10/03)
A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions ind
Indole derivatives and pharmaceutical use thereof
-
, (2008/06/13)
The invention relates to the compound of formula (I) STR1 wherein A represents an unsubstituted ethenyl group in the trans (E) configuration or a physiologically acceptable salt or metabilically labile ester thereof which are antagonists of excitatory ami
