153436-22-7 Usage
Uses
Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).
Biological Activity
Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .
Safety Profile
A poison by
intravenous route. When heated to
decomposition it emits toxic vapors of NOx
and Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 153436-22-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,4,3 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 153436-22:
(8*1)+(7*5)+(6*3)+(5*4)+(4*3)+(3*6)+(2*2)+(1*2)=117
117 % 10 = 7
So 153436-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H12Cl2N2O3.Na/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11;/h1-9,22H,(H,21,23)(H,24,25);/q;+1/p-1/b7-6+;
153436-22-7Relevant academic research and scientific papers
Indole derivatives and pharmaceutical use thereof
-
, (2008/06/13)
The invention relates to the compound of formula (I) STR1 wherein A represents an unsubstituted ethenyl group in the trans (E) configuration or a physiologically acceptable salt or metabilically labile ester thereof which are antagonists of excitatory ami
