153463-33-3Relevant academic research and scientific papers
New Synthesis of α-Amino Acid N-Carboxy Anhydrides through Baeyer-Villiger Oxidation of α-Keto β-Lactams
Palomo, Claudio,Aizpurua, Jesus M.,Ganboa, Inaki,Carreaux, Francois,Cuevas, Carmen,et al.
, p. 3123 - 3130 (2007/10/02)
A conceptually new route for the generation of optically active α-aminoacid N-carboxy anhydrides (NCAs) and hence α-amino acid derivatives is described.The strategy developed is simple and consists of the oxidation of α-hydroxy β-lactams to the correspond
Asymmetric synthesis of α-keto β-lactams via [2+2] cycloaddition reaction: A concise approach to optically active α-hydroxy β-lactams and β-alkyl(aryl)isoserines
Palomo,Aizpurua,Miranda,Mielgo,Odriozola
, p. 6325 - 6328 (2007/10/02)
The cycloaddition reaction of the Evans-Sjogren ketenes to imines, followed by α-hydroxylation of the resulting cycloadducts provides an efficient general asymmetric synthesis of α-keto β-lactams and derivatives.
