153473-24-6

Basic information

• Product Name: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-4-(3-NITROPYRIDIN-2-YL)PIPERAZINE;4-(3-Nitro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester ,97%;tert-butyl 4-(3-nitropyridin-2-yl)piperazine-1- carboxylate;2-(4-BOC-Piperazino)-3-nitropyridine;tert-Butyl 4-(3-nitro-2-pyridyl)piperazine-1-carboxylate;1-Boc-4-(3-nitro-2-pyridinyl)piperazine;tert-Butyl 4-(3-nitropyridine-2-yl)piperazine-1-carboxylate
• CAS NO: 153473-24-6
• Molecular Formula: C₁₄H₂₀N₄O₄
• Molecular Weight: 308.333
• Product Categories: pharmacetical
• Mol File: 153473-24-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 447.8 °C at 760 mmHg
• Flash Point: 224.6 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 3.26E-08mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• PKA: 4.38±0.29(Predicted)
• CAS DataBase Reference: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(153473-24-6)
• EPA Substance Registry System: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(153473-24-6)

Safety Data

• Statements: 25
• Safety Statements: 45
• RIDADR: 2811
• Hazardous Substances Data: 153473-24-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C14H20N4O4/c1-14(2,3)22-13(19)17-9-7-16(8-10-17)12-11(18(20)21)5-4-6-15-12/h4-6H,7-10H2,1-3H3

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 1480-87-1 2-fluoro-3-nitropyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 87394-48-7 1-(3-nitro-2-pyridinyl)piperazine 

Downstream Products

• 136817-55-5 delavirdine 
• 1316754-35-4 2-(4-((1-benzyl-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-32-1 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-33-2 1-(1-benzyl-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 1316754-21-8 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 136816-84-7 1-<(5-fluoroindol-2-yl)carbonyl>-4-<3-<(methylethyl)amino>-2-pyridyl>piperazine 
• 153473-26-8 4-(3-Methylamino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 136816-76-7 1-(indolyl-2-carbonyl)-4-<3-<(1-methylethyl)amino>pyridyl>-piperazine 
• 403502-22-7 [2-chloro-5-(3-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-21-6 [2-chloro-5-(4-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-23-8 [2-chloro-5-(2-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-17-0 [4-[3-(isopropylamino)-2-pyridyl]piperazino]-[5-(4-nitrophenyl)-1H-2-pyrrolyl]methanone 
• 403502-19-2 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(3-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 
• 403502-46-5 [5-(4-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 

Relevant articles and documents

Oligomer modified diaromatic substituted compounds

Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligome

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT 6 receptor antagonists

Starting from the potent and selective but poorly brain penetrant 5-HT 6 receptor antagonist SB-271046, a successful strategy for improving brain penetration was adopted involving conformational constraint with concomitant reduction in hydrogen bond count. This provided a series of bicyclic heteroarylpiperazines with high 5-HT6 receptor affinity. 5-Chloroindole 699929 combined high 5-HT6 receptor affinity with excellent brain penetration and also had good oral bioavailability in both rat and dog.