153473-69-9

Basic information

• Product Name: 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine
• Synonyms: 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine
• CAS NO: 153473-69-9
• Molecular Weight: 418.375
• Mol File: 153473-69-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine(153473-69-9)
• EPA Substance Registry System: 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine(153473-69-9)

Safety Data

• Hazardous Substances Data: 153473-69-9(Hazardous Substances Data)

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 136818-95-6 (1H-indol-2-yl)(piperazin-1-yl)methanone 

Downstream Products

• 153473-70-2 [4-(2-Amino-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(1H-indol-2-yl)-methanone 

Relevant articles and documents

Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.