153475-20-8

Upstream product

• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 937-63-3 p-Tolyl chlorothionoformate 
• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 

Downstream Products

• 222048-05-7 N-[(2R,3S,5R)-5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide 
• 151807-43-1 2-[(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide 
• 146557-61-1 5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine 
• 146557-59-7 5'-O-(tert-butyldiphenylsilyl)-3'-C-methyleneformyl-3'-deoxythymidine 
• 146557-58-6 3-C-allyl-1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-erythro-pentofuranosyl]thymine 

Relevant academic research and scientific papers

Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

We report the synthesis and biological properties of three modified dinucleotides T*G G*T and T*T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence