Bioorganic and Medicinal Chemistry Letters p. 627 - 632 (1999)
Update date:2022-07-29
Topics: Experimental Chemical Inhibition Strategy HIV-1
Druillennec, Sabine
Meudal, Herve
Roques, Bernard P.
Fournie-Zaluski, Marie-Claude
We report the synthesis and biological properties of three modified dinucleotides T*G G*T and T*T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence
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