Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

DOI: 10.1016/S0960-894X(99)00052-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 627 - 632 (1999)

Update date:2022-07-29

Topics: Experimental Chemical Inhibition Strategy HIV-1

Authors:

Druillennec, Sabine

Meudal, Herve

Roques, Bernard P.

Fournie-Zaluski, Marie-Claude

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Article abstract of DOI:10.1016/S0960-894X(99)00052-9

We report the synthesis and biological properties of three modified dinucleotides T*G G*T and T*T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence

Full text of DOI:10.1016/S0960-894X(99)00052-9

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