153492-07-0

Upstream product

• 83966-23-8 1-Amino-5-pentane 
• 153492-04-7 2-Hydroxy-1,2,3-propanetricarboxylic acid 2-tert-butyl 1,3-bis(p-nitrophenyl) triester 
• 114340-52-2 3-(tert-butoxycarbonyl)-3-hydroxypentanedioic acid 
• 114340-51-1 2-tert-butyl 1,3-dimethyl 2-hydroxypropane-1,2,3-tricarboxylate 
• 83948-51-0 1-<(tert-Butoxycarbonyl)amino>-5-pentane 
• 53798-96-2 1,5-dimethyl citrate 

Downstream Products

• 153492-20-7 2-{[5-(Acetyl-benzyloxy-amino)-pentylcarbamoyl]-methyl}-N-{5-[benzyloxy-(3-methoxycarbonyl-propionyl)-amino]-pentyl}-2-hydroxy-succinamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of Novel Citrate-Based Siderophores and Siderophore-β-Lactam Conjugates. Iron Transport-Mediated Drug Delivery Systems

The synthesis of analogs of arthrobactin (5), a microbial iron chelator, and its imide 8 are described.The differentially protected citric acid residue 31 served as the key intermediate in making conjugates having a generalized structure 14 with two representative carbacephalosporin units, 15 and 16.Both conjugates, 49 and 51, showed antibiotic activity, while conjugate 51 obtained from β-lactam 16 bearing a phenylglycyl side chain was shown to be more effective.