63243-76-5Relevant articles and documents
Synthesis, biological screening, in silico study and fingerprint applications of novel 1, 2, 4-triazole derivatives
Chandramohan, Vivek,Govindaiah, Shivaraja,Khan, Ghouse,Shetty P, Raghurama,Sreenivasa, Swamy
, (2020)
A series of novel 1,2,4 triazole derivatives were synthesized by treating 4-bromo-2-(4H-1,2,4-triazole-3-yl)aniline (4) with different substituted benzene sulfonyl chlorides 5(a-f) and benzyl bromides 7(a-e). IR, 1H-NMR, 13C-NMR, and
Visible-light-promoted oxidative halogenation of (hetero)arenes
Jiang, Xuefeng,Li, Yiming,Lu, Lingling
supporting information, p. 5989 - 5994 (2020/10/18)
Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.
RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides
Lu, Chengrong,Gong, Chao,Zhao, Bei,Hu, Lijuan,Yao, Yingming
, p. 1154 - 1159 (2018/02/10)
The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.
