153563-93-0Relevant academic research and scientific papers
Asymmetric Synthesis by Enzymatic Hydrolysis of Prochiral Dienol Diacetate.
Duhamel, Pierre,Renouf, Philippe,Cahard, Dominique,Yebga, Albert,Poirier, Jean-Marie
, p. 2447 - 2450 (1993)
Enzymatic hydrolysis of prochiral dienol diacetate 1 by Candida cylindracea lipase (CCL) leads to the keto enol acetate 2 in high yield with an enantiometric excess>98percent.The S configuration of the asymmetric center was assigned.
Asymmetric hydrolysis of pro-chiral 3,3-disubstituted 2,4-diacetoxy-cyclohexa-1,4-dienes
Renouf, Philippe,Poirier, Jean-Marie,Duhamel, Pierre
, p. 1739 - 1745 (2007/10/03)
Asymmetric enzymatic hydrolysis of pro-chiral 3,3-disubstituted 2,4-diacetoxycyclohexa-1,4-dienes 2 affords in high yields optically pure 2,2-disubstituted 3-acetoxycyclohex-3-enones 1 (>98% ee). Under mild conditions Candida cylindracea lipase (enzyme/substrate ratio = 2%) hydrolyses specifically the pro-S enol ester function of the pro-chiral starting material 2.
