153579-37-4Relevant academic research and scientific papers
Kinetic resolution of β-alkenyl-, β-alkynyl- and β-flavenyl-substituted β-hydroxy esters in asymmetric dehydration
Min, Hee Lee,Eui, Ta Choi,Kim, Dajung,Yoon, Min Lee,Yong, Sun Park
experimental part, p. 5630 - 5637 (2009/05/27)
Catalytic asymmetric dehydration of β-alkenyl- or alkynyl-substituted β-hydroxy esters by kinetic resolution has been investigated with five different chiral ligands 3-7. The kinetic resolution of a variety of racemic β-hydroxy tert-butyl esters in the presence of a prolinol chiral ligand and BrZnCH2CO2tBu provided highly enantio-enriched β-hydroxy esters 9-22 with selectivity factors ranging from 11 to 59. In addition, the application of this asymmetric synthetic methodology to the preparation of enantio-enriched flavene derivatives 23-29 is demonstrated. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Direct NMR assay of the enantiomeric purity of chiral β-hydroxy esters by using quinine as chiral solvating agent
Uccello-Barretta,Pini,Mastantuono,Salvadori
, p. 1965 - 1972 (2007/10/03)
The use of quinine as a chiral solvating agent for NMR spectroscopy affords a general method for the enantiomeric purity determination of β-hydroxyesters. The ester group represents the most suitable probe for the measurements, which can be optimized by varying the molar ratio ester/quinine, the total concentration or the temperature.
A cobalt-phosphine complex as mediator in the formation of carbon-carbon bonds
Orsini,Pelizzoni,Pulici
, p. 1 - 3 (2007/10/02)
The tetrakis(trimethylphospine)cobalt(0) complex, [Co{P(CH3)3}4], in either stoichiometric or catalytic amounts, was shown to be an efficient mediator for a one-pot Reformatsky-type reaction between activated halogen derivatives (esters, amides, lactones) and carbonyl compounds (aldehydes, ketones) to produce a variety of alcohols.
