153600-16-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-5-trichloromethylpyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its unique chemical properties and reactivity, contributing to the development of various medicinal compounds.
Used in Agrochemical Industry:
2,4-Dichloro-5-trichloromethylpyrimidine is used as an intermediate in the synthesis of agrochemicals, specifically in the production of herbicides and insecticides, due to its potential to create effective and targeted biologically active molecules.
Safety Note:
2,4-Dichloro-5-trichloromethylpyrimidine is a highly reactive and hazardous substance, and proper safety precautions should be taken when handling it to ensure the well-being of individuals and the environment.

Upstream product

• 1780-31-0 2,6-dichloro-5-methylpyrimidine 
• 65-71-4 thymin 

Downstream Products

• 54-20-6 5-trifluoromethyluracil 

Relevant academic research and scientific papers

A new synthesis of 5-trifluoromethyluracil

5-Trifluoromethyluracil, an important intermediate for the preparation of the antiviral trifluridine, is obtained by chlorinating thymine to give the new 2,4-dichloro-5-trichloromethylpyrimidine. Reacting the latter with hydrogen fluoride yields the new 2,4-difluoro-5-trifluoromethylpyrimidine, and hydrolysis with water gives 5-trifluoromethyluracil in high purity and good yield.

Process for the preparation of 5-(trifluoromethyl)-uracil, and the novel compounds 2,4-dichloro-5-trichloromethyl-pyrimidine and 2,4-difluoro-5-trifluoromethyl-pyrimidine

5-Trifluoromethyl-uracil is obtained by chlorinating thymine under mild conditions, further chlorinating the resulting 2,4-dichloro-5-methyl-pyrimidine under drastic conditions to give 2,4-dichloro-5-trichloromethylpyrimidine, reacting the latter with a fluorinating agent to give 2,4-fluorinated and/or -chlorinated 5- trifluoromethylpyrimidines and subjecting these to hydrolysis. The novel chemical compounds 2,4-dichloro- 5-trichloromethylpyrimidine and 2,4-difluoro-5-trifluoromethylpyrimidine are obtained in the course of this process.