153610-11-8

Basic information

• Product Name: 3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI)
• Synonyms: 3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI);(3R-cis)-4-AMinotetrahydro-3-furanol;cis-4-Aminotetrahydrofuran-3-ol
• CAS NO: 153610-11-8
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.12
• Product Categories: VARIOUSAMINE;Amines, Heterocycles, Intermediates
• Mol File: 153610-11-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 231.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.222±0.06 g/cm3(Predicted)
• PKA: 14.12±0.40(Predicted)
• CAS DataBase Reference: 3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI)(153610-11-8)
• EPA Substance Registry System: 3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI)(153610-11-8)

Safety Data

• Hazardous Substances Data: 153610-11-8(Hazardous Substances Data)

Usage

Description

3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI) is a novel, optically active heterocyclic amino alcohol with unique structural properties. It serves as a versatile building block for the synthesis of biologically active molecules, including pharmaceuticals and other bioactive compounds. Its ability to act as both a monosaccharide mimetic structure and an amino acid surrogate makes it a valuable asset in the development of new therapeutic agents.

Uses

Used in Pharmaceutical Industry:
3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI) is used as a building block for the development of biologically active molecules due to its unique structural properties and versatility. It plays a crucial role in the synthesis of pharmaceutical compounds, contributing to the creation of novel drugs with potential therapeutic applications.
Used in Drug Design and Synthesis:
3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI) is used as a monosaccharide mimetic structure and an amino acid surrogate in drug design and synthesis. Its ability to mimic the properties of monosaccharides and amino acids allows researchers to develop new drug candidates with improved pharmacological profiles and enhanced bioavailability.
Used in Research and Development:
3-Furanol,4-aminotetrahydro-,(3R-cis)-(9CI) is used as a key component in the research and development of new biologically active molecules. Its unique properties make it an attractive candidate for further investigation and exploration in various scientific fields, including medicinal chemistry, biochemistry, and molecular biology.

Upstream product

• 285-69-8 3,4-epoxytetrahydrofuran 
• 183184-50-1 trans-4-azido-3-hydroxytetrahydrofuran 
• 190792-68-8 [(3R,4S)-4-azidotetrahydrofuran-3-yl]oxytrimethylsilane 
• 1430230-65-1 (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxytetrahydrofuran 
• 1430230-65-1 (3R,4S)-3-tert-butoxycarbonylamino-4-hydroxytetrahydrofuran 
• 153610-13-0 (3S,4R)-4-Azido-tetrahydro-furan-3-ol 

Downstream Products

• 1430230-65-1 tert-butyl ((3S,4R)-4-hydroxytetrahydrofuran-3-yl)carbamate 
• 1421582-97-9 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]ethyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3S,4R)-4-hydroxytetrahydrofuran-3-yl]benzamide 
• 1421582-94-6 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3S,4R)-4-hydroxytetrahydrofuran-3-yl]benzamide 
• 1421582-95-7 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]benzamide 
• 5834-36-6 3-oxa-6-azabicyclo[3.1.0]hexane 
• 215940-74-2 [(S)-1-((3S,4R)-4-Hydroxy-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester 
• 1421583-08-5 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]ethyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3S,4S)-4-hydroxytetrahydrofuran-3-yl]benzamide 
• 1421582-96-8 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]ethyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]benzamide 
• 1421766-35-9 C₁₇H₁₈Cl₂N₄O₄ 
• 1430230-65-1 tert-butyl 4-hydroxytetrahydrofuran-3-ylcarbamate 
• 1430230-65-1 (±)-trans-3-tert-butoxycarbonylamino-4-hydroxytetrahydrofuran 

Relevant articles and documents

New Chiral Building Blocks and their Application to the Construction of Chiral Aminoalcohols: Enantiomerically Pure cis- and trans-3-Mesyloxy-4-hydroxy Tetrahydrofurans

The enantioselective synthesis of 3-mesyloxy-4-hydroxy tetrahydrofurans is described, starting from the chiral pool.The usefulness of these building blocks is illustrated by the synthesis of enantiomerically pure 3-amino-4-hydroxy-tetrahydrofurans.

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS

Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)