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285-69-8

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285-69-8 Usage

Uses

Different sources of media describe the Uses of 285-69-8 differently. You can refer to the following data:
1. 3,6-Dioxabicyclo[3.1.0]hexane was a reagent used in making various degradable polymers from epoxides using a versatile dinuclear chromium catalyst.
2. 3,6-Dioxabicyclo[3.1.0]hexane was a reagent used in making various degradable polymers from epoxides using a versatile dinuclear chromium catalyst

Chemical Properties

clear yellow liquid

Check Digit Verification of cas no

The CAS Registry Mumber 285-69-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 285-69:
(5*2)+(4*8)+(3*5)+(2*6)+(1*9)=78
78 % 10 = 8
So 285-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O2/c1-3-4(6-3)2-5-1/h3-4H,1-2H2/t3-,4+

285-69-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,6-dioxabicyclo[3.1.0]hexane

1.2 Other means of identification

Product number -
Other names 3,6-Dioxabicyclo[3.1.0]hexane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:285-69-8 SDS

285-69-8Synthetic route

2,5-dihydrofuran
1708-29-8

2,5-dihydrofuran

3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran at 0 - 20℃;84.6%
With mCPHA In dichloromethane at 0 - 20℃;84.6%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane Heating;71%
trans-4-chloro-tetrahydro-furan-3-ol

trans-4-chloro-tetrahydro-furan-3-ol

3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

Conditions
ConditionsYield
With copper(I) oxide; diisopropylbenzene
With sodium hydroxide
With calcium hydroxide; water
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

trans-4-amino-3-hydroxytetrahydrofuran
144870-96-2

trans-4-amino-3-hydroxytetrahydrofuran

Conditions
ConditionsYield
With ammonium hydroxide at 85℃; for 0.5h; microwave irradiation;100%
With ammonium hydroxide In isopropyl alcohol at 80℃; for 12h;95%
With ammonia In water; isopropyl alcohol at 80℃; for 12h;95%
With ammonium hydroxide
With ammonium hydroxide at 100℃; for 14h;
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

4-amino-3-hydroxytetrahydrofuran
144870-96-2

4-amino-3-hydroxytetrahydrofuran

Conditions
ConditionsYield
With ammonium hydroxide In isopropyl alcohol at 80℃; for 15h;100%
With ammonia; water In isopropyl alcohol at 80℃; for 18h;96.8%
With ammonia In water; isopropyl alcohol at 80℃; for 18h;96.8%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde
805250-31-1

4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

4′-(((3R,4R)/(3S,4S)-4-hydroxytetrahydrofuran-3-yl)oxy)-2',6'-dimethylbiphenyl-3-carbaldehyde

4′-(((3R,4R)/(3S,4S)-4-hydroxytetrahydrofuran-3-yl)oxy)-2',6'-dimethylbiphenyl-3-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In ethanol at 100℃; for 1.5h; Microwave irradiation;100%
With potassium carbonate In ethanol at 100℃; for 1.5h; Inert atmosphere; Microwave irradiation;100%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

4-bromo-phenol
106-41-2

4-bromo-phenol

trans-4-(4-bromophenoxy)tetrahydrofuran-3-ol

trans-4-(4-bromophenoxy)tetrahydrofuran-3-ol

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; caesium carbonate In 1,4-dioxane for 18h; Reflux; Inert atmosphere;100%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

carbon dioxide
124-38-9

carbon dioxide

tetrahydrofuro[3,4-d]1,3-dioxolan-2-one

tetrahydrofuro[3,4-d]1,3-dioxolan-2-one

Conditions
ConditionsYield
With tetrabutylammomium bromide In neat (no solvent) at 100℃; for 12h; chemoselective reaction;98%
With C68H105N2O5YZn; tetrabutylammomium bromide In butanone at 70℃; under 7600.51 Torr; for 24h; Temperature; Autoclave;92%
With C32H24Al2Cl8N2O6*2C4H8O; tetrabutylammomium bromide In neat (no solvent) at 85℃; under 7500.75 Torr; for 40h; Schlenk technique;89%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

tert-butyl 4-(2-fluoro-4-hydroxyphenyl)piperazine-1-carboxylate
501126-38-1

tert-butyl 4-(2-fluoro-4-hydroxyphenyl)piperazine-1-carboxylate

tert-butyl 4-(2-fluoro-4-((4-hydroxytetrahydrofuran-3-yl)oxy)phenyl)piperazine-1-carboxylate

tert-butyl 4-(2-fluoro-4-((4-hydroxytetrahydrofuran-3-yl)oxy)phenyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane at 100℃; for 16h;98%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

benzene 1,3,5-triyl triformate

benzene 1,3,5-triyl triformate

C11H10Cl2O3

C11H10Cl2O3

Conditions
ConditionsYield
With aluminum (III) chloride; palladium diacetate; triethylamine; triphenylphosphine; lithium chloride In N,N-dimethyl-formamide at 85℃; for 20h; Sealed tube; Inert atmosphere;96%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

t-butylsulfonamide
34813-49-5

t-butylsulfonamide

(+/-)-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-tert-butylsulfonamide

(+/-)-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-tert-butylsulfonamide

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 96h;95%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

trimethylsilylazide
4648-54-8

trimethylsilylazide

((3R,4S)-4-azidotetrahydrofuran-3-yloxy)trimethylsilane
190792-68-8

((3R,4S)-4-azidotetrahydrofuran-3-yloxy)trimethylsilane

Conditions
ConditionsYield
With (1R,2R)-salen catalyst In diethyl ether at 25℃;93%
With (R,R)-(salen)Cr(III) 1.) Et2O, 15 min, 2.) Et2O, RT, 18 h; Multistep reaction;
With (R,R)-Cr(N2(CH)2CHCH(CH2)4)(OC6H2(t-Bu)2)2N3 for 24h; Ambient temperature; further reagent: chiral (salen)Cr(III)Cl complex;97 % Turnov.
chiral Cr(salen) In various solvent(s) at 20℃; for 18h; Ring cleavage;
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

tert.-butyl lithium
594-19-4

tert.-butyl lithium

4,4-dimethyl-3-methylenepentane-1,2-diol

4,4-dimethyl-3-methylenepentane-1,2-diol

Conditions
ConditionsYield
In tetrahydrofuran; pentane at -78 - 20℃; for 1h;93%
In tetrahydrofuran at -78 - 25℃;93%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

carbon monoxide
201230-82-2

carbon monoxide

3,6-dioxabicyclo[3.2.0]heptan-7-one
1309803-08-4

3,6-dioxabicyclo[3.2.0]heptan-7-one

Conditions
ConditionsYield
With dicobalt octacarbonyl; (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III) In 1,2-dimethoxyethane at 70℃; under 1034.32 - 25858.1 Torr; for 16h; Inert atmosphere;93%
With dicobalt octacarbonyl; tetraphenylporphyrinchromium(III) chloride In tetrahydrofuran at 70℃; under 25858.1 Torr; for 16h; Inert atmosphere;91%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

sec.-butyllithium
598-30-1

sec.-butyllithium

4-methyl-3-methylenehexane-1,2-diol

4-methyl-3-methylenehexane-1,2-diol

Conditions
ConditionsYield
In tetrahydrofuran; hexane at -78 - 20℃; for 1h;92%
In tetrahydrofuran at -78 - 25℃;92%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

trimethylsulphonium iodide
2181-42-2

trimethylsulphonium iodide

tetrahydrofuran-4-methylidene-3-ol
390381-85-8

tetrahydrofuran-4-methylidene-3-ol

Conditions
ConditionsYield
Stage #1: trimethylsulphonium iodide With n-butyllithium In tetrahydrofuran; hexane at -10℃; for 0.5h;
Stage #2: 3,4-epoxytetrahydrofuran In tetrahydrofuran; hexane at -10 - 20℃; Further stages.;
92%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

bromobenzene
108-86-1

bromobenzene

(3S,4R)-4-phenyltetrahydrofuran-3-ol
130871-09-9

(3S,4R)-4-phenyltetrahydrofuran-3-ol

Conditions
ConditionsYield
With [2,2]bipyridinyl; manganese; (1,2-dimethoxyethane)dichloronickel(II); bis(η5((1R,2S,5R)-5-methyl-2-[prop-2-yl]-cyclohex-1-yl)cyclopentadienyl)-titanium dichloride; triethylamine hydrochloride at 20℃; for 12h; Inert atmosphere; Glovebox; Autoclave; enantioselective reaction;91%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

trimethylsilylazide
4648-54-8

trimethylsilylazide

(3R,4S)-3-azido-4-trimethylsiloxytetrahydrofurane

(3R,4S)-3-azido-4-trimethylsiloxytetrahydrofurane

Conditions
ConditionsYield
With (1S,2S)-salen catalyst In diethyl ether at 25℃;90%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

3-methyleneheptane-1,2-diol

3-methyleneheptane-1,2-diol

Conditions
ConditionsYield
In tetrahydrofuran; hexane at -78 - 20℃; for 1h;90%
In tetrahydrofuran; hexane at -78 - 25℃; for 1h;90%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

dimethyl amine
124-40-3

dimethyl amine

trans-3-(dimethylamino)-4-hydroxytetrahydrofuran

trans-3-(dimethylamino)-4-hydroxytetrahydrofuran

Conditions
ConditionsYield
In water at 50 - 55℃;90%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

tert-butyl N-(6-aminohexyl)carbamate
51857-17-1

tert-butyl N-(6-aminohexyl)carbamate

OC4H6OHHNC6H12NHCOOC4H9

OC4H6OHHNC6H12NHCOOC4H9

Conditions
ConditionsYield
In water at 105℃; microwave irradiation;90%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

N-(tert-butoxycarbonyl)-1,7-heptanediamine
99733-18-3

N-(tert-butoxycarbonyl)-1,7-heptanediamine

OC4H6OH2NC7H14NHCOOC4H9

OC4H6OH2NC7H14NHCOOC4H9

Conditions
ConditionsYield
In water at 105℃; microwave irradiation;90%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

carbon dioxide
124-38-9

carbon dioxide

(3aRS,7aSR)-tetrahydrofuro[3,4-d][1,3]dioxol-2-one
1379481-94-3

(3aRS,7aSR)-tetrahydrofuro[3,4-d][1,3]dioxol-2-one

Conditions
ConditionsYield
With C21H12Cl6NO4V; tetrabutylammomium bromide In neat (no solvent) at 85℃; under 7500.75 Torr; for 18h;89%
With C80H128La2N2O10*2C4H8O; tetrabutylammomium bromide at 100℃; under 7500.75 Torr; for 40h;89%
With (2-hydroxyphenyl)diphenyl(propyl)phosphonium iodide In neat (no solvent) at 80℃; under 18751.9 Torr; for 24h; Autoclave;82%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

cyclopropylmagnesium bromide
23719-80-4

cyclopropylmagnesium bromide

(±)-trans-4-cyclopropyltetrahydrofuran-3-ol

(±)-trans-4-cyclopropyltetrahydrofuran-3-ol

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;87.3%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

1-amino-4-[(tert-butyloxycarbonyl)amino]butane
68076-36-8

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

OC4H6OHHNC4H8NHCOOC4H9

OC4H6OHHNC4H8NHCOOC4H9

Conditions
ConditionsYield
In water at 105℃; microwave irradiation;87%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

CH2Cl2:MeOH

CH2Cl2:MeOH

1-[(4-chlorophenyl)methyl]piperazine
23145-88-2

1-[(4-chlorophenyl)methyl]piperazine

(+/-)-trans-4-[4-(4-chlorobenzyl)-piperazin-1-yl]-tetrahydrofuran-3-ol

(+/-)-trans-4-[4-(4-chlorobenzyl)-piperazin-1-yl]-tetrahydrofuran-3-ol

Conditions
ConditionsYield
With ammonium hydroxide In ethanol; dichloromethane87%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

2,4,6-triisopropylbenzene sulfonamide
105536-22-9

2,4,6-triisopropylbenzene sulfonamide

(+/-)-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-2,4,6-triisoproplybenzenesulfonamide

(+/-)-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-2,4,6-triisoproplybenzenesulfonamide

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 96h;86%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

5-tert-butoxycarbonylamino-1-aminopentane
51644-96-3

5-tert-butoxycarbonylamino-1-aminopentane

OC4H6OHHNC5H10NHCOOC4H9

OC4H6OHHNC5H10NHCOOC4H9

Conditions
ConditionsYield
In water at 105℃; microwave irradiation;85%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

4‐(tert‐butoxycarbonylamino)benzylamine
220298-96-4

4‐(tert‐butoxycarbonylamino)benzylamine

OC4H6OH2NC7H6NHCOOC4H9

OC4H6OH2NC7H6NHCOOC4H9

Conditions
ConditionsYield
In water at 105℃; microwave irradiation;85%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

C4H6O4S

C4H6O4S

Conditions
ConditionsYield
With C25H20AlCl6NO4; sulfur dioxide; tetrabutylammomium bromide In acetonitrile at 70℃; for 16h; Flow reactor; chemoselective reaction;85%
3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

iodobenzene
591-50-4

iodobenzene

3-hydroxy 4-phenylselenotetrahydrofuran

3-hydroxy 4-phenylselenotetrahydrofuran

Conditions
ConditionsYield
With selenium; potassium phosphate; copper(l) chloride In dimethyl sulfoxide at 20 - 130℃; for 29h; Inert atmosphere;84.9%
morpholine
110-91-8

morpholine

3,4-epoxytetrahydrofuran
285-69-8

3,4-epoxytetrahydrofuran

trans-3-hydroxy-4-morpholinotetrahydrofuran

trans-3-hydroxy-4-morpholinotetrahydrofuran

Conditions
ConditionsYield
at 75 - 80℃; for 3h;84%

285-69-8Upstream product

285-69-8Relevant articles and documents

-

Anderson,Dewey

, p. 306 (1977)

-

-

Zajac et al.

, p. 21,22 (1968)

-

FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

-

Paragraph 0377-0379, (2019/10/10)

Provided are a class of compounds as shown in formula (I) as FGFR4 inhibitors, and pharmaceutically acceptable salts thereof, preparation methods therefor and the use thereof in the preparation of drugs for treating FGFR4-related diseases.

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

-

Paragraph 01202; 01203, (2015/04/28)

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

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