153645-33-1

Basic information

• Product Name: N-Phenylethyl hydroxyacetamide
• Synonyms: N-Phenylethyl hydroxyacetamide
• CAS NO: 153645-33-1
• Molecular Weight: 179.219
• Mol File: 153645-33-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-Phenylethyl hydroxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenylethyl hydroxyacetamide(153645-33-1)
• EPA Substance Registry System: N-Phenylethyl hydroxyacetamide(153645-33-1)

Safety Data

• Hazardous Substances Data: 153645-33-1(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 623-50-7 ethyl 2-hydroxyacetate 
• 36293-01-3 2-chloro-N-((1S)-1-phenylethyl)acetamide 
• 79-14-1 glycolic Acid 

Relevant articles and documents

Synthesis and characterization of N-alkyl hydroxyacetamides

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Alkylation of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide using a phase transfer catalyst (PTC) for practical asymmetric syntheses of α-amino acid derivatives

The chiral auxiliary mediated stereoselective alkylation reaction of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide (1) using a phase transfer catalyst (PTC) is described. Alkylation of 1 using 18-crown-6 as a PTC for liquid-solid extraction of KOH in toluene gives best results. This methodology provides a practical protocol for the preparation of a variety of enantio-enriched unnatural α-amino acid derivatives up to 83:17 enantiomeric ratio.