1536481-10-3Relevant academic research and scientific papers
Amine-catalyzed asymmetric cross-aldol reactions using heterofunctionalized acetaldehydes as nucleophiles
Kano, Taichi,Sakamoto, Ryu,Maruoka, Keiji
supporting information, p. 944 - 947 (2014/03/21)
Various heterofunctionalized acetaldehydes were successfully employed in an amine-catalyzed asymmetric cross-aldol reaction, affording a variety of synthetically useful 1,2-difunctionalized compounds such as 1,2-diols and 1,2-aminoalcohols. With this method, both syn- and anti-1,2-difunctionalized compounds were obtained from the same set of reactants by using the appropriate amine catalyst.
