153652-73-4

Basic information

• Product Name: 3-tert-butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate
• Synonyms: 3,5-oxazolidinedicarboxylic acid, 2-(4-methoxyphenyl)-4-phenyl-, 3-(1,1-dimethylethyl) 5-methyl ester, (2R,4S,5R)-; 3-tert-Butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate
• CAS NO: 153652-73-4
• Molecular Formula: C₂₃H₂₇NO₆
• Molecular Weight: 413.4636
• Mol File: 153652-73-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 527.1°C at 760 mmHg
• Flash Point: 272.6°C
• Density: 1.188g/cm³
• Vapor Pressure: 3.37E-11mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 3-tert-butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate(153652-73-4)
• EPA Substance Registry System: 3-tert-butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate(153652-73-4)

Safety Data

• Hazardous Substances Data: 153652-73-4(Hazardous Substances Data)

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 124605-42-1 methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate 

Downstream Products

• 1054786-40-1 C₅₇H₆₁Cl₆NO₁₇ 
• 114915-20-7 Docetaxel 
• 155396-69-3 (2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid 

Relevant articles and documents

Taxoids, preparation thereof, and pharmaceutical compositions containing same

Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or an alkenyl, alkynyl, cycloalkyl, optionally substituted cycloalkenyl or phenyl radical, or an aromatic 5- or 6-membered heterocyclic radical; and Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl, thenoyl or furoyl radical or a radical R2 --O--CO, where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl, or heterocycl radical, and R3 is an aromatic heterocyclic, alkyl, alkenyl, alkynyl cycloalkyl, phenyl or naphthyl radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral activity. STR1

2-Monosubstituted-1,3-Oxazolidines as Improved Protective Groups of N-Boc-Phenylisoserine in Docetaxel Preparation

A new route for semisynthetic docetaxel, 1, is desribed using 2-monosubstituted-4-phenyl-1,3-oxazolidine-5-carboxylic acids in esterification of 7,10-O-diTroc-10-desacetylbaccatin III (4).Subsequent deprotection of esters 10(+10') afforded title compound 1 without removal of the Boc group.