15366-20-8Relevant academic research and scientific papers
A kind of optical active pharmaceutical process for the preparation of intermediates
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, (2016/10/17)
The invention relates to a preparation method of an optical active compound, represented by formula I, or a hydrochloride of the optical active compound by taking a compound with optical activity as a starting material. Raw materials of the preparation method are cheap and easily available; no splitting is needed; the whole technological operation is simple and convenient; cost is low; pollution on environment is less; and the preparation method is suitable for industrialized production. In the formula I, n is 1 or 2 or 3.
A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids
Li, Shi-Guang,Portela-Cubillo, Fernando,Zard, Samir Z.
supporting information, p. 1888 - 1891 (2016/05/19)
A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.
