153704-74-6

Basic information

• Product Name: (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol
• Synonyms: (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol
• CAS NO: 153704-74-6
• Molecular Weight: 381.588
• Mol File: 153704-74-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol(153704-74-6)
• EPA Substance Registry System: (2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol(153704-74-6)

Safety Data

• Hazardous Substances Data: 153704-74-6(Hazardous Substances Data)

Upstream product

• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 121745-57-1 (2R,3R)-3-azido-3-phenyl-propane-1,2diol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 125414-45-1 (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol 

Downstream Products

• 218797-62-7 methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester 
• 198829-58-2 (2S,3R)-1-(tert-butoxycarbonyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>-3-phenylaziridine 
• 1415502-37-2 (6S,7R)-2,2,3,3,11,11-hexamethyl-9-oxo-7-phenyl-4,10-dioxa-8-aza-3-siladodecan-6-yl 4-nitrobenzoate 
• 218797-66-1 (2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane 
• 218797-68-3 (2S,3S)-2-<(tert-butoxycarbonyl)amino>-3-phenylbutanol 
• 207122-29-0 (2S)-2-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-3-phenylpropane 
• 90731-57-0 (βS)-N-(tert-butoxycarbonyl)-β-methyl-L-phenylalanine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 146499-46-9 (2R,3R)-3-tert-butoxycarbonylamino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane 

Relevant articles and documents

IMIDAZOPYRIDINE COMPOUNDS

[Problem] An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. [Means for Solution] It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.

Total Synthesis of Mugineic Acid. Efficient Use of the Phenyl Group as the Carboxyl Synthon

Stereoselective total synthesis of mugineic acid (1), a unique phytosiderophore from roots of barley, has been achieved from readily available (2S,3S)- and (2R,3R)-2,3-epoxycinnamyl alcohols (5) and (6).The key step is the oxidation of the phenyl group to the carboxylic acid by use of the ruthenium trichloride-sodium metaperiodate system.