125414-45-1Relevant articles and documents
Divergent and scalable synthesis of α-hydroxy/keto-β-amino acid analogues by the catalytic enantioselective addition of glyoxylate cyanohydrin to imines
Nanjo, Takeshi,Zhang, Xuan,Tokuhiro, Yusuke,Takemoto, Yoshiji
, p. 10087 - 10092 (2019)
The catalytic enantioselective addition of glyoxylate cyanohydrin to imines to afford α-keto-β-amino acid equivalents is reported. Sterically tuned aminobenzothiadiazine catalysts provided high yields and stereoselectivities (up to 100% yield, 99% ee, >99
IMIDAZOPYRIDINE COMPOUNDS
-
Paragraph 0372, (2014/04/03)
[Problem] An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. [Means for Solution] It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.
Total Synthesis of Mugineic Acid. Efficient Use of the Phenyl Group as the Carboxyl Synthon
Matsuura, Fumiyoshi,Hamada, Yasumasa,Shioiri, Takayuki
, p. 8211 - 8222 (2007/10/02)
Stereoselective total synthesis of mugineic acid (1), a unique phytosiderophore from roots of barley, has been achieved from readily available (2S,3S)- and (2R,3R)-2,3-epoxycinnamyl alcohols (5) and (6).The key step is the oxidation of the phenyl group to the carboxylic acid by use of the ruthenium trichloride-sodium metaperiodate system.
