1537170-85-6Relevant articles and documents
STEROIDS AND PROTEIN-CONJUGATES THEREOF
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, (2018/05/27)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
1537170-85-6
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Basic information
- Product Name: DBCO-PEG4-Acid
- Synonyms: DBCO-PEG4-Acid;Dibenzocyclooctyne-PEG4-acid;ADIBO-PEG4-acid 90% (HPLC);ADIBO-PEG4-acid
- CAS NO:1537170-85-6
- Molecular Formula: C30H36N2O8
- Molecular Weight: 552.62
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1537170-85-6.mol
- Article Data: 2
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 839.7±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: Yellow to Orange/Solid or Viscous Liquid
- Density: 1.27±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: Soluble in DMSO, DCM, DMF
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: DBCO-PEG4-Acid(CAS DataBase Reference)
- NIST Chemistry Reference: DBCO-PEG4-Acid(1537170-85-6)
- EPA Substance Registry System: DBCO-PEG4-Acid(1537170-85-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1537170-85-6(Hazardous Substances Data)
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1537170-85-6 Usage
Description
DBCO-PEG4-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.Uses
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG spacer adds hydrophilicity to the product to decrease aggregation.Check Digit Verification of cas no
The CAS Registry Mumber 1537170-85-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,7,1,7 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.Calculate Digit Verification of CAS Registry Number 1537170-85:
(9*1)+(8*5)+(7*3)+(6*7)+(5*1)+(4*7)+(3*0)+(2*8)+(1*5)=166
166 % 10 = 6
So 1537170-85-6 is a valid CAS Registry Number.
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1537170-85-6Downstream Products
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DBCO-PEG4-Acid
