1427004-19-0 Usage
Uses
Used in Bioconjugation:
DBCO-PEG4-NHS Ester is used as a bioconjugation agent for the incorporation of the cyclooctyne moiety into amine-containing compounds or biomolecules. This enables the formation of stable triazole linkages with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst.
Used in Protein-Peptide Conjugates:
In the pharmaceutical industry, DBCO-PEG4-NHS Ester is used as a key component in the creation of protein-peptide conjugates, allowing for the efficient and specific attachment of peptides to proteins.
Used in Antibody-Enzyme or Antibody-Drug Conjugates:
In the field of antibody-drug conjugates (ADCs), DBCO-PEG4-NHS Ester is employed as a crucial element for the formation of antibody-enzyme or antibody-drug conjugates, enhancing the targeting and delivery of therapeutic agents to specific cells.
Used in Protein or Peptide-Oligonucleotide Conjugates:
DBCO-PEG4-NHS Ester is utilized as a conjugation agent in the development of protein or peptide-oligonucleotide conjugates, which have potential applications in gene therapy and other genetic research areas.
Used in Surface Modification:
In the materials science and engineering industry, DBCO-PEG4-NHS Ester is used for surface modification, allowing for the covalent attachment of various molecules to surfaces, such as in the creation of biocompatible coatings or the development of sensors.
Overall, DBCO-PEG4-NHS Ester is a versatile and valuable reagent in the fields of bioconjugation, pharmaceuticals, gene therapy, and materials science, thanks to its ability to facilitate copper-free Click Chemistry reactions and improve the efficiency of various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1427004-19-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,0,0 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1427004-19:
(9*1)+(8*4)+(7*2)+(6*7)+(5*0)+(4*0)+(3*4)+(2*1)+(1*9)=120
120 % 10 = 0
So 1427004-19-0 is a valid CAS Registry Number.
1427004-19-0Relevant articles and documents
STEROIDS AND ANTIBODY-CONJUGATES THEREOF
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Paragraph 00416, (2019/07/20)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF
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Paragraph 0752; 0770, (2019/11/28)
Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.
STEROIDS AND PROTEIN-CONJUGATES THEREOF
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, (2018/05/27)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
Tubulysin compounds, methods of making and use
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Page/Page column 71, (2016/08/07)
Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
